This antinociceptive effect may be mediated, at least in part, by the activation of endogenous opioid
receptors and/or by the inhibition of TRPV1 and TRPA1 channels.
were reported to be negatively correlated with oxytocin (Bicknell and Leng, 1982; Douglas et al.
Inhibitory neurotransmitters include endogenous opioids
(enkephalins and endorphins), serotonin, and norepinephrine.
This suggests that alcohol and opiates have similar pharmacological effects and that alcohol consumption may be modified by manipulating the endogenous opioid
receptor genes and alcohol dependence among Taiwanese Han.
also seem to reduce inflammatory pain in peripheral tissues.
1] receptor coupling inhibits the endogenous opioid
system by decreasing the sensitivity of both [mu] and [kappa] opioid receptors (Mackie 2008).
The endogenous opioid
system and clinical pain management.
Dynorphin is an endogenous opioid
peptide with a high affinity for the kappa-opioid receptor and its up-regulation in the spinal cord coincide whit an elevation in pain thresholds in rats during pregnancy and parturition (BRADSHAW et al.
Among the neurotransmitters that affect the release of gonadal secretions are endogenous opioid
peptides like enkephalin, dynorphin, beta endorphins etc.
Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid
peptides: evidence for opiate and nonopiate receptor participation.
Endorphins are endogenous opioid
polypeptide compounds produced during pain and orgasm, and they work as natural pain relievers (8).