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endogenous opioid

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endogenous opioid,
an opiate-like substance, such as an endorphin, produced by the body.

opioid
1. any synthetic narcotic that has opiate-like activities but is not derived from opium.
2. denoting naturally occurring peptides, e.g. enkephalins, that exert opiate-like effects by interacting with opiate receptors of cell membranes.

endogenous opioid
opioid receptors
specific receptor sites for opioids, named for the drugs which have a high binding affinity for them. The main ones are mu (morphine), kappa (opioid agonist-antagonists such as pentazocine) and delta (enkephalin endogenous opioids). Subtypes exist and others, such as sigma and epsilon, have been identified.


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Endogenous opioid peptides, such as beta-endorphin and enkephalin, function to inhibit pain and they are also the 'feel good' substances that are released following high levels of exercise or love.
A team led by Jon-Kar Zubieta of the University of Michigan aimed to measure the impact on two chemical messenger systems in the brain--the endogenous opioid and dopamine systems--when pain was induced and a placebo "treatment" was administered at regular intervals.
Some argue that a small number of addicts require lifelong substitution therapy owing to a relative endogenous opioid deficiency.
 
 
 
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