endogenous opioid


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endogenous opioid

an opiate-like substance, such as an endorphin, produced by the body.

opioid

1. any synthetic narcotic that has opiate-like activities but is not derived from opium.
2. denoting naturally occurring peptides, e.g. enkephalins, that exert opiate-like effects by interacting with opiate receptors of cell membranes.

endogenous opioid
opioid receptors
specific receptor sites for opioids, named for the drugs which have a high binding affinity for them. The main ones are mu (morphine), kappa (opioid agonist-antagonists such as pentazocine) and delta (enkephalin endogenous opioids). Subtypes exist and others, such as sigma and epsilon, have been identified.
References in periodicals archive ?
This antinociceptive effect may be mediated, at least in part, by the activation of endogenous opioid receptors and/or by the inhibition of TRPV1 and TRPA1 channels.
Endogenous opioids were reported to be negatively correlated with oxytocin (Bicknell and Leng, 1982; Douglas et al.
Inhibitory neurotransmitters include endogenous opioids (enkephalins and endorphins), serotonin, and norepinephrine.
This suggests that alcohol and opiates have similar pharmacological effects and that alcohol consumption may be modified by manipulating the endogenous opioid system.
1] receptor coupling inhibits the endogenous opioid system by decreasing the sensitivity of both [mu] and [kappa] opioid receptors (Mackie 2008).
The endogenous opioid system and clinical pain management.
Dynorphin is an endogenous opioid peptide with a high affinity for the kappa-opioid receptor and its up-regulation in the spinal cord coincide whit an elevation in pain thresholds in rats during pregnancy and parturition (BRADSHAW et al.
Among the neurotransmitters that affect the release of gonadal secretions are endogenous opioid peptides like enkephalin, dynorphin, beta endorphins etc.
Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: evidence for opiate and nonopiate receptor participation.
Endorphins are endogenous opioid polypeptide compounds produced during pain and orgasm, and they work as natural pain relievers (8).