MRC2

(redirected from endocytic receptor)

MRC2

A gene on chromosome 17q23.2 that encodes a C-type lectin domain protein which may play a role as a lectin receptor by internalising glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. Mannose receptor C-type 2 may play roles in plasminogen activation by controlling the extracellular level of PLAUR/PLAU; in cellular uptake and remodelling, and in degradation of extracellular collagen matrices; in cancer and chronic tissue-destructive diseases acting on collagen turnover; and may participate in extracellular matrix remodelling in concert with matrix metalloproteinases.
References in periodicals archive ?
It was found that CTGF is normally reabsorbed almost completely in proximal tubules via megalin (an endocytic receptor involved in protein uptake) and that elevated urinary CTGF excretion largely reflects dysfunction of the proximal tubules.
Megalin, an endocytic receptor on the luminal surface of proximal tubules, binds [beta]2-microglobulin, and it is then metabolized in kidney lysosomes (16).
Posterboard Number: B220, Program Number: 3244 Megalin and Related Endocytic Receptors Mediate Uptake of Retinoid Binding Proteins in the Retinal Pigment Epithelium Session Date: Tuesday, May 8, 2007, 3:00 p.
The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.