MRC2

(redirected from endocytic receptor)

MRC2

A gene on chromosome 17q23.2 that encodes a C-type lectin domain protein which may play a role as a lectin receptor by internalising glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. Mannose receptor C-type 2 may play roles in plasminogen activation by controlling the extracellular level of PLAUR/PLAU; in cellular uptake and remodelling, and in degradation of extracellular collagen matrices; in cancer and chronic tissue-destructive diseases acting on collagen turnover; and may participate in extracellular matrix remodelling in concert with matrix metalloproteinases.
References in periodicals archive ?
The MR is an endocytic receptor that recognizes carbohydrate moieties, which is continuously recycled between the plasma membrane and the early endosomal compartment with its bound ligand [24].
The endocytic receptor CD89 showed only low expression on moDCs.
Preferential antigen targeting and presentation can be achieved through targeting of the antigens to endocytic receptors on APCs.
Several endocytic receptors have been previously described as candidates for antigen specific targeting to HLA class II [13-16].
In the present study we tried to improve the efficiency of this assay by enhancing uptake of HLA class I antigens via targeting of endocytic receptors on either monocytes or moDCs.
Megalin is an endocytic receptor with a high affinity for the Cbl transport protein transcobalamin II that can mediate Cbl cellular uptake through endocytosis of the transcobalamin II-Cbl complex [27].
As an endocytic receptor for multiple ligands, megalin also actively participates in amyloid-[beta] (A[beta]) clearance [54], and a recent study showed that blood-brain barrier megalin-knockout mice model developed neurodegeneration and Alzheimer's disease-like symptoms [55].
Birn, "Megalin and cubilin: multifunctional endocytic receptors," Nature Reviews Molecular Cell Biology, vol.
LRP is a large (approximately 600 kDa) endocytic receptor with four clusters of ligand-binding repeats.
It was found that CTGF is normally reabsorbed almost completely in proximal tubules via megalin (an endocytic receptor involved in protein uptake) and that elevated urinary CTGF excretion largely reflects dysfunction of the proximal tubules.
Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.
The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.