EPA's proposed Endocrine Disruptor
Screening Program substantially reflects the EDSTAC recommendations.
But the testing procedures for determining whether a chemical is even a suspected endocrine disruptor
are still quite primitive and their reliability is unknown.
Furthermore, new approaches are needed to examine the effects of mixtures of endocrine disruptors
on disease susceptibility and etiology, as examination of one endocrine disruptor
at a time is likely to underestimate the combined risk from simultaneous exposure to multiple endocrine disruptors
org) shows we can drastically reduce our consumption of the endocrine disruptors
bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) by making a few basic changes in our dietary practices.
These proceedings cover all the presentations from iSmithers' inaugural Endocrine Disruptors
2011 conference which addressed key topics related to the evaluation of adverse effects on the endocrine system and corresponding regulatory requirements.
Because of increased understanding of the mechanisms by which hormones and chemicals that mimic hormones work, it has recently become clear that endocrine disruptors
need to be studied at much lower doses.
Interaction with Estrogen Receptors.
The Endocrine Society, on the other hand, proposes a streamlined version of the EPA's 1996 definition of an endocrine disruptor
to include "exogenous chemicals or chemical mixtures that interfere with any aspect of hormone action," irrespective of adverse effects or specific mechanisms.
It BPA is now considered to be an endocrine disruptor
and experts said it could lead to the early sexual development of children and may cause cancer.
The announcement moved forward the Endocrine Disruptor
Screening Program, which is currently proceeding on 3 fronts: 1) performing scientific and technical testing needed to validate the endocrine disruptor
screens and tests; 2) setting priorities for selecting chemicals for initial screening and testing; and 3) developing the policies and procedures the Agency will use to require testing.
Theo Colborn, an endocrine disruptor
specialist with the World Wildlife Fund and a coauthor of Our Stolen Future, five percent of American babies have had toxic exposure to polychlorinated biphenyls (PCBs) in breast milk high enough to affect intelligence.
The agency then formed the Endocrine Disruptor
Screening and Testing Advisory Committee (EDSTAC).