endocrine disruptor


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endocrine disruptor

A substance which interferes with the synthesis, secretion, transport, binding, action or elimination of natural hormones in the body that are responsible for development, behaviour, fertility and maintenance of homeostasis (normal cell metabolism).

Examples
DDT, polychlorinated biphenyls, bisphenol A, polybrominated diphenyl ethers, phthalates.

endocrine disruptor

(dĭs-rŭp′tĕr)
A chemical that may imitate or block the function of natural hormones if it is absorbed by the body. Many pesticides and plasticizing compounds, e.g., phthalates, are thought to disrupt endocrine pathways, esp. if they are absorbed by pregnant women during embryonic and fetal development.
References in periodicals archive ?
But the testing procedures for determining whether a chemical is even a suspected endocrine disruptor are still quite primitive and their reliability is unknown.
Furthermore, new approaches are needed to examine the effects of mixtures of endocrine disruptors on disease susceptibility and etiology, as examination of one endocrine disruptor at a time is likely to underestimate the combined risk from simultaneous exposure to multiple endocrine disruptors.
org) shows we can drastically reduce our consumption of the endocrine disruptors bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) by making a few basic changes in our dietary practices.
These proceedings cover all the presentations from iSmithers' inaugural Endocrine Disruptors 2011 conference which addressed key topics related to the evaluation of adverse effects on the endocrine system and corresponding regulatory requirements.
Because of increased understanding of the mechanisms by which hormones and chemicals that mimic hormones work, it has recently become clear that endocrine disruptors need to be studied at much lower doses.
The Endocrine Society, on the other hand, proposes a streamlined version of the EPA's 1996 definition of an endocrine disruptor to include "exogenous chemicals or chemical mixtures that interfere with any aspect of hormone action," irrespective of adverse effects or specific mechanisms.
It BPA is now considered to be an endocrine disruptor and experts said it could lead to the early sexual development of children and may cause cancer.
The announcement moved forward the Endocrine Disruptor Screening Program, which is currently proceeding on 3 fronts: 1) performing scientific and technical testing needed to validate the endocrine disruptor screens and tests; 2) setting priorities for selecting chemicals for initial screening and testing; and 3) developing the policies and procedures the Agency will use to require testing.
Theo Colborn, an endocrine disruptor specialist with the World Wildlife Fund and a coauthor of Our Stolen Future, five percent of American babies have had toxic exposure to polychlorinated biphenyls (PCBs) in breast milk high enough to affect intelligence.
The agency then formed the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC).