endochondral ossification


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ossification

 [os″ĭ-fĭ-ka´shun]
formation of or conversion into bone or a bony substance.
ectopic ossification a pathological condition in which bone arises in tissues not in the osseous system and in connective tissues usually not manifesting osteogenic properties.
endochondral ossification ossification that occurs in and replaces cartilage.
heterotrophic ossification metaplastic ossification.
intramembranous ossification ossification of bone that occurs in and replaces connective tissue.
metaplastic ossification the development of bony substance in normally soft body structures; called also heterotrophic ossification.

en·do·chon·dral os·si·fi·ca·tion

formation of osseous tissue by the replacement of calcified cartilage; long bones grow in length by endochondral ossification at the epiphysial cartilage plate where osteoblasts form bone trabeculae on a framework of calcified cartilage.

endochondral ossification

n.
The formation of bone in which a cartilage template is gradually replaced by a bone matrix, as in the formation of long bones or in osteoarthritic ossification of synovial cartilage.

en·do·chon·dral os·si·fi·ca·tion

(en'dō-kon'drăl os'i-fi-kā'shŭn)
Formation of osseous tissue by the replacement of calcified cartilage; long bones grow in length by endochondral ossification at the epiphysial cartilage plate where osteoblasts form bone trabeculae on a framework of calcified cartilage.
Synonym(s): intrachondral ossification.
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ENDOCHONDRAL OSSIFICATION: Ossification process in a long bone; (A) progression from embryo to young adult, (B) microscopic view of an epiphyseal disk
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ENDOCHONDRAL OSSIFICATION

endochondral ossification

The formation of bone in cartilage, as in the formation of long bones, involving the destruction and removal of cartilage and the formation of osseous tissue in the space formerly occupied by the cartilage. See: illustration
illustration
See also: ossification

endochondral ossification

Bone formation occurring within cartilage, in which cartilage is replaced by bone. This is the main process of bone formation and extension during fetal life and childhood.

en·do·chon·dral os·si·fi·ca·tion

(en'dō-kon'drăl os'i-fi-kā'shŭn)
Formation of osseous tissue by replacement of calcified cartilage.

endochondral


endochondral ossification
see enchondral ossification.
References in periodicals archive ?
The tumors arise from the cartilages (thyroid most frequently) of the larynx in areas of endochondral ossification, with a typical histology of numerous giant cells containing many nuclei that are histologically indistinguishable from the nuclei of the stromal spindle cells surrounding the giant cells.
Histomorphometry of the day 14 fracture calluses showed a significant delay in endochondral ossification because the Pb-treated mice had a 4- to 5-fold increase in unmineralized cartilage with a commensurate decrease in bone (Figure 4).
This abnormal pattern of cartilage matrix assembly explains well the abnormalities in endochondral ossification leading to shortness and deformity of the skeletal segments.