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endochondral bone |
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Fracture healing involves primary recruitment, proliferation, and differentiation of both osteoprogenitors (osteoblast progenitors), for intramembranous ossification, and undifferentiated mesenchymal cells, for endochondral bone formation (Barnes et al. In the early stage of otoscierosis (otospongiosis), the endochondral bone is replaced by foci of spongy new bone. An in vitra study found that lead inhibits parathyroid hormone-related peptide (PTHrP) and transforming growth factor-[beta]1, proteins that decrease the rate of maturation of chondrocytes in endochondral bone formation (Zuscik et al. |
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