All subcategories of AGC and AIS, except atypical endometrial cells, require colposcopy with endocervical curettage, HPV testing, and--in women older than 35 or at risk for endometrial hyperplasia (for example, polycystic ovarian syndrome)--endometrial biopsy.
In women with CIN 1 who previously had HGSIL or AGC-NOS, three options are to be considered: 1) diagnostic excisional procedure, except in adolescents and pregnant women; 2) observation with colposcopy and cytology at six-month intervals for one year if the colposcopy is satisfactory and endocervical curettage is negative; and 3) review all findings and revise interpretation, if appropriate.
In addition, several small clusters of similar neoplastic cells were identified in the endometrial and endocervical curettage
specimens taken at the same time as the cone (Figure 1, B).
Adequate histologic follow-up results (cervical biopsy with or without endocervical curettage and LEEP/ cone biopsy) were available for 2192 of 4273 women, with an overall follow-up biopsy rate of 51.
These patients included 207 cases with follow-up endocervical curettage but without cervical biopsy and 1874 cases with follow-up Pap tests only or without any recorded follow-up.
, cone margins, and residual adenocarcinoma in situ of the cervix.
Up until last year, no matter how hard I pressed on the curette during office endocervical curettage
(EGG), about 10% of the pathology reports came back stating that the tissue was insufficient.
performed at the time of initial LEEP showed HSIL in 18 women.
These women received a repeat Pap smear and directed biopsies or endocervical curettage
of all lesions of the cervix.
Follow-up included review and recording of surgical pathology results, including cervical biopsies, endocervical curettages
, cone excisions, loop electrosurgical excision procedures, endometrial biopsies and curettages, and hysterectomies.