endocardiosis

endocardiosis

common cause of cardiac disease in the dog. Characterized by chronic fibrosis and nodular thickening of the free edges of the atrioventicular valves. In the worst cases the valve cusps are distorted converting a minor leak into a massive incompetence. Leads to congestive heart failure. There is no specific cause.
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Echocardiographic evidence of right AV regurgitation and postmortem findings of valvular endocardiosis, engorgement of the vena cava, and hepatic chronic passive congestion are consistent with right-sided heart failure secondary to AV valve insufficiency.
Se le diagnostico una insuficiencia de la valvula mitral por una endocardiosis valvular en febrero del ano 2008, por lo que se le medico con Enalapril de 5 mg (1,25 mg cada 12 horas).
La enfermedad degenerativa valvular (EDV), endocardiosis o enfermedad valvular cronica, es la patologia cardiovascular con mayor prevalencia, 75% de los pacientes caninos llevados a consulta cardiologica son diagnosticados en diferentes estadios de la enfermedad (2,9,11,14).
Pathologic findings in a zebu with spongiform encephalopathy, Switzerland, 2004 Site Finding Vertebral column Severe degeneration of intervertebral discs with ankylosing spondylarthrosis Joints of extremities Degenerative joint disease Liver Biliary cysts (affecting 60% of the liver) Kidney Tubular cysts; mild interstitial nephritis with glomerulosclerosis and tubular atrophy Urinary bladder Multiple papillomas Abdominal cavity Multiple foci of fat necrosis Cardiovascular system Mild coronary arteriosclerosis; mild valvular endocardiosis (mitral valve) Mediastinal lymph nodes Focal metastatic neuroendocrine tumor (origin unknown) Central nervous system Spongiform encephalopathy; metabolic encephalopathy (hepatoencephalopathy) Table 2.
It is also called endocardiosis or valvular insufficiency and is most common in smaller dogs, especially the poodle, fox terrier, chihuahua and, in particular, the Cavalier King Charles.
Additional histologic findings included moderate mesangioproliferative glomerulopathy with glomerulosclerosis, mild proliferative bronchitis, mild pneumoconiosis, mild splenic arteriosclerosis, mild hepatic hemosiderosis, mild endocardiosis, mild proliferative enterocolitis, ductular adenitis of the uropygial gland, an ovarian cystadenoma, mild rhabdomyolysis, and cataracts.
Reported clinical Clinical Case Breed Sex Age (yr) Site findings outcome Edema of limbs Pulmonary edema Dog 1 Boxer M 15 HB E Respiratory distress Dog 2 Great M 10 HB Walking SD Dane difficulties Edema of limbs Dog 3 Boxer M 14 HB Emaciati E Enlarged abdomen Anorexia Dog 4 Boxer M * 9 HB Apathy E Dyspnea Case Significant gross IHC lesions Anasarca Ascites Dog 1 Hemoperi Positive Hydropericardium Pulmonary edema Hemothorax Dog 2 Nutmeg Positive Endocardiosis Anasarca Ascites Dog 3 Hemopericardium Hemothor Positive Nutmeg liver Pulmonary edema Subcutaneous edema Dog 4 Cutaneous mast cell tumor Positive Pulmonary edema SD, Spontaneous death.
On postmortem examination, chronic renal disease and moderate cardiac fibrosis and endocardiosis were observed, but these conditions were considered to be age-related.