feedback inhibition

(redirected from end product inhibition)
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Related to end product inhibition: feedback inhibition

feed·back in·hi·bi·tion

inhibition of activity by an end product of the pathway of which that activity is a part; for example, thyroliberin stimulates thyroglobulin production, and thyroglobulin decreases thyrotropin formation.

feedback inhibition

n.
A cellular control mechanism in which an enzyme that catalyzes the production of a particular substance in the cell is inhibited when that substance has accumulated to a certain level, thereby balancing the amount provided with the amount needed.

feed·back in·hi·bi·tion

(fēd'bak in'hi-bish'ŭn)
Inhibition of activity by an end product of the pathway of which that activity is a part.
Synonym(s): feedback mechanism.

feedback inhibition

the inhibition of the synthesis of a molecule by a control mechanism initiated by the increase in concentration of that molecule.

Kiliani,

H., German chemist, 1855-1945.
Kiliani-Fischer reaction - Synonym(s): Kiliani-Fischer synthesis
Kiliani-Fischer synthesis - a synthetic procedure for the extension of the carbon atom chain of aldoses by treatment with cyanide. Synonym(s): feedback inhibition; Kiliani-Fischer reaction

inhibition

arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.