end points


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end points,

n.pl 1. the preestablished steps that, when completed, mark the achievement of a treatment goal.
n.pl 2. the clinical indications that a specific infectious condition has been lessened or eliminated altogether.
References in periodicals archive ?
5, 2015 /PRNewswire/ -- A new white paper from the Amyloidosis Research Consortium concludes that NT-proBNP, a functional biomarker predictive of survival, is a clinically and analytically validated functional biomarker that should be accepted as a surrogate end point in pivotal clinical trials to accelerate the development of therapeutics for AL amyloidosis.
Although the development of in vitro methods is occurring more systematically than ever before, it continues to be a slow and uncertain procedure to model the complex biological processes that underlie toxicological assessments for end points such as subchronic and chronic toxicity, reproductive toxicity, and carcinogenicity.
Making the strategic decisions regarding how best to extend greater agility to end points, provide for greater trustworthiness and create a more manageable infrastructure have become more pressing as IT infrastructure costs and risks continue to mount.
Of normotensive subjects, 6% developed one of these end points, compared with 17% of those with sustained hypertension--a significant difference.
Along with phenotypic anchoring to existing end points, it is essential that the use of toxicogenomics data in a screening or regulatory setting not depend exclusively on achieving complete understanding of the functional implications of individual gene, protein, or metabolite changes.
As users and business requirements become more demanding, end points are becoming harder to manage and control Making the strategic decisions regarding how best to extend greater agility to end points, provide for greater trustworthiness, and create a more manageable infrastructure have become more pressing as costs and risks have continued to mount.
Also, individual compounds were found to trigger specific pathways within the nongenomic signaling network leading to different end points.
The use of biomarkers that function as surrogate end points in clinical trials may allow product developers to design more-efficient and shorter trials while offering the opportunity to diagnose preclinical disease.
Second, we describe steps taken to inform the selection of priority health end points for environmental health tracking, which included a synthesis of review articles on environmental health indicators and an examination of existing national environmental emissions, health, and health care databases to understand trends in environmentally related health end points.
The Session Initiation Protocol (SIP), designed to become the industry standard for multimedia applications, continues to bolster demand for IP end points that operate under this protocol.
2001), there are compelling reasons for the establishment of public databases that house not only such transcript profiling data but also the associated toxicological end points.
Drug developers are increasingly using surrogate end points to establish their oncology agents' efficacy.