enantiomers


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enantiomers (i·nanˑ·tē··merz),

n.pl molecules that are nonsuperimposable mirror images of one another resulting from the chirality exhibited by organic compounds (containing an asymmetrical carbon); enantiomers differ in their ability to rotate plane-polarized light. Also called
enantiomorphs. See also chirality.
References in periodicals archive ?
Obviousness of Enantiomers over Prior Art Racemates (126)
To date, there have been several methods disclosed in the literature for preparing d-threo enantiomer of methylphenidate, the process reported first by Patrick etal, describes use of expensive resolving agent 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate in the resolution of dl-threo- methylphenidate, The Journal of Pharmacology and Experimental Therapeutics,241:152-158(1987).
held that the anticipation argument failed because the genus patent only disclosed the existence of enantiomers generally; there was no specific disclosure of enantiomers of the racemic mixture of clopidogrel, nor was there disclosure of how to separate the enantiomers.
Therefore, the first aim of this study was to develop and validate an assay for simultaneous measurement of concentrations and ratios of AM, MA, MDA, MDMA, and MDEA enantiomers in oral fluid.
The most infamous case of the two enantiomers of a racemic drug being highly different in their effects on the human body is that of thalidomide* The drug was originally released as a means of combating morning sickness, and one enantiomer was successful at alleviating these symptoms.
The enantiomer ratios (the amount of one enantiomer expressed as percentage of the total amount of the pair of compounds) of some monoterpenoic compounds in the blackcurrant aroma samples are presented in Table 4.
Inhibition of tyrosine hydroxylase by R and S enantiomers of salsolinol, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline.
The therapeutic properties of citalopram apparently reside in just one of the enantiomers, S-citalopram.
Concern over possible or demonstrated negative side effects from one of the enantiomers has accelerated the effort to market single enantiomer or chiral pure drugs.
Under the terms of the agreement, Sepracor has exclusively licensed to Janssen all of Sepracor's worldwide rights to develop and market norcisapride enantiomers.
CTP-221 has a specific deuterium modification pattern which optimally slows the interconversion of enantiomers in vivo, thus enabling administration of the more potent S-enantiomer with minimal exposure to the R-enantiomer.