The association of high fever with enamel hypomineralisation during infancy has recently been explained by an experimental study showing that persistent high fever influenced the process of enamel formation, producing disorientation of enamel prisms
and crystal-free areas [Tunk et al.
The research team compared proline repeats in amphibian and animal models and discovered that when the repeats are short, such as in frogs, teeth will not have the enamel prisms
that are responsible for the strength of human enamel.
At high magnification, enamel prisms appear hollow and may contain enamel tubules.
Enamel prisms are anchored at the enamel-dentine junction and extend to the occlusal surface with differing orientations characteristic of different taxa (Koenigswald, 1982; Boyde et al.
In several of the high-magnification micrographs, the fibrous, crystallitic nature of the enamel prisms and interprismatic material is evident, and prisms appear to be hollow (Fig.
Enamel comprises about 95% of substituted hydroxyapatite crystals, arranged in bundles of enamel prisms
2-5 microns in diameter extending from dentine to the enamel surface.