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emtricitabine |
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emtricitabine Emtriva Pharmacologic class: Nucleoside reverse transcriptase inhibitor Therapeutic class: Antiretroviral Pregnancy risk category B FDA Boxed Warning• Drug has caused lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) when used alone or in combination with other antiretrovirals. ActionInhibits activity of HIV-1 reverse transcriptase by competing with natural substrate and by its incorporation into nascent viral DNA, thereby halting viral replication AvailabilityCapsules: 200 mg Oral solution: 10 mg/ml in 170-ml bottles ⊘Indications and dosages ➣ HIV-1 infection, with other antiretrovirals Adults ages 18 and older: 200-mg capsule P.O. daily or 240 mg (24 ml) oral solution P.O. once daily Children ages 3 months to 17 years weighing more than 33 kg (73 lb): 200-mg capsule P.O. once daily Children ages 3 months to 17 years weighing less than 33 kg (73 lb): 6 mg/kg oral solution P.O. daily to maximum of 240 mg (24 ml) once daily Children ages 0 to 3 months: 3 mg/kg oral solution P.O. once daily Dosage adjustment• Renal impairment Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Give with or without food.
Adverse reactionsCNS: dizziness, headache, insomnia, abnormal dreams, depression, peripheral neuritis or neuropathy, paresthesia EENT: rhinitis GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia Hepatic: hepatotoxicity Metabolic: cushingoid appearance (buffalo hump, moon face), lactic acidosis Musculoskeletal: joint pain, myalgia Respiratory: increased cough Skin: rash, skin discoloration (hyperpigmentation on palms and soles) Other: body fat redistribution InteractionsDrug-drug. Tenofovir disoproxil fumarate: increased emtricitabine effect Drug-diagnostic tests. Alanine aminotransferase, amylase, aspartate aminotransferase, bilirubin, creatine kinase, lipase, triglycerides: increased levels Glucose: increased or decreased level Neutrophils: decreased count Patient monitoring☞ Monitor closely (especially in females and obese patients) for signs and symptoms of lactic acidosis and hepatotoxicity, even if patient doesn't have marked transaminase elevations. Patient teaching• Tell patient to take a missed dose as soon as he remembers. However, if it's almost time for next dose, tell him to skip the missed dose and take next dose as scheduled. |
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? Mentioned in | ? References in periodicals archive | |
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5%; and emtricitabine, due to mutation M184V/I related to lamivudine pressure [emtricitabine was not used in Cameroon]), efavirenz, and nevirapine (10. FDA announced the approval of FTC (brand name Emtriva, generic name emtricitabine, former brand name Coviracil[TM]) on July 2, 2003. today announced that it has begun to file registrations for ATRIPLA(TM) (efavirenz 600 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg), a once-daily, single tablet regimen for the treatment of HIV-1 infection in adults, with health authorities in those developing countries around the world where many HIV-positive people live. |
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