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emtricitabine |
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emtricitabine, a retroviral. indication This drug is used with other retrovirals to treat HIV infection. contraindication Known hypersensitivity to this drug prohibits its use. adverse effects Adverse effects of this drug include headache, abnormal dreams, depression, dizziness, insomnia, neuropathy, paresthesia, arthralgia, myalgia, cough, change in body fat distribution, rash, and skin discoloration. Common side effects include nausea, vomiting, diarrhea, anorexia, abdominal pain, and dyspepsia. emtricitabine Emtriva Pharmacologic class: Nucleoside reverse transcriptase inhibitor Therapeutic class: Antiretroviral Pregnancy risk category B FDA Boxed Warning• Drug has caused lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) when used alone or in combination with other antiretrovirals. ActionInhibits activity of HIV-1 reverse transcriptase by competing with natural substrate and by its incorporation into nascent viral DNA, thereby halting viral replication AvailabilityCapsules: 200 mg Oral solution: 10 mg/ml in 170-ml bottles ⊘Indications and dosages ➣ HIV-1 infection, with other antiretrovirals Adults ages 18 and older: 200-mg capsule P.O. daily or 240 mg (24 ml) oral solution P.O. once daily Children ages 3 months to 17 years weighing more than 33 kg (73 lb): 200-mg capsule P.O. once daily Children ages 3 months to 17 years weighing less than 33 kg (73 lb): 6 mg/kg oral solution P.O. daily to maximum of 240 mg (24 ml) once daily Children ages 0 to 3 months: 3 mg/kg oral solution P.O. once daily Dosage adjustment• Renal impairment Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Give with or without food.
Adverse reactionsCNS: dizziness, headache, insomnia, abnormal dreams, depression, peripheral neuritis or neuropathy, paresthesia EENT: rhinitis GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia Hepatic: hepatotoxicity Metabolic: cushingoid appearance (buffalo hump, moon face), lactic acidosis Musculoskeletal: joint pain, myalgia Respiratory: increased cough Skin: rash, skin discoloration (hyperpigmentation on palms and soles) Other: body fat redistribution InteractionsDrug-drug. Tenofovir disoproxil fumarate: increased emtricitabine effect Drug-diagnostic tests. Alanine aminotransferase, amylase, aspartate aminotransferase, bilirubin, creatine kinase, lipase, triglycerides: increased levels Glucose: increased or decreased level Neutrophils: decreased count Patient monitoring☞ Monitor closely (especially in females and obese patients) for signs and symptoms of lactic acidosis and hepatotoxicity, even if patient doesn't have marked transaminase elevations. Patient teaching• Tell patient to take a missed dose as soon as he remembers. However, if it's almost time for next dose, tell him to skip the missed dose and take next dose as scheduled. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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During the clinical trial, the researchers combined both with two other standard retroviral drugs, tenofovir and emtricitabine. Ordinarily, tenofovir alone, or in a fixed-dose combination with emtricitabine, is used in the treatment of HIV/AIDS. In subjects with any indication for HIV therapy, the combination of tenofovir and emtricitabine (available co-formulated in a single pill, Truvada), is considered the first choice. |
emtricitabine |
EMTCC EMTD EMTE EMTEC EMTECH EMTEL emTeX EMTF EMTFR EMTI EMTIC EMTISM EMTM EMTM2N EMTN EMTO EMTOX EMTP EMTPA EMTPF EMTPL EMTPP EMTR EMTRAC emtricitabine emtricitabine and tenofovir disoproxil fumarateEmtriva EMTS Emtsa EMTSC EMTT EMTU EMTV EMTY emu emu emu emu emu emu EMÜ Emu Bitter Emu Bush emu bushes Emu novaehollandiae Emu oil emu parade Emu wren emu-bob Emu-wren emu-wrens EMU8000 EMUA EMUAS | ||||||||
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