1] Furthermore, the worldwide rise of antibiotic resistance makes empirical therapy
increasingly difficult, especially in resource-limited settings.
The agenda, presented by a faculty of 18 experts, covered new diagnostic techniques, debates on pre-emptive and empirical therapy
, and a range of individual case studies which looked at Candida infections in haematology patients, transplant patients, neonates, patients with HIV, and patients requiring renal replacement therapy.
SI was defined as follows: i) any clinical or microbiologically documented infection that did not exist at the time of initial evaluation, but developed during empirical therapy
or within 1 week after discontinuation of therapy, and ii) fever that responded to empirical therapy
, but recurred after an afebrile period of 48 h during empirical therapy
Based on the clinical signs and findings of the physical examination, the owner elected for conservative, empirical therapy
with triple-antibiotic ophthalmic solution (OS; 1 drop OS q8h; neomycin and polymyxin B sulfates and gramicidin ophthalmic solution).
In the absence of rapid, detailed diagnostic information, doctors typically administer empirical therapy
based on historical experience.
They found that while appropriate empirical therapy
was not associated with a significant decrease in mortality, they did see a reduction in the mean LOS by 7 percent in patients who received appropriate empirical therapy
as compared to those who did not.
In rural settings, where facilities for culture/sensitivity of the causative organisms are not present, empirical therapy
with antibiotics based on proper guidelines may be acceptable.
The significant increase in the incidence of MRSA in community as well as hospital acquired infections has resulted in a need for empirical therapy
of ABSSSI that is effective against MRSA.
Ambulatory pH testing should be done to substantiate a GERD diagnosis for those who have not responded to empirical therapy
and who have had unremarkable endoscopy and manometry.
Such information can assist empirical therapy
in cases where specimens are not usually submitted to the laboratory (e.
Injectible Tobramycin is the drug of choice used in the initial empirical therapy
for VAP and is also well known for its nephrotoxicity.
These results indicate a need for changes with regard to empirical therapy
of anaerobic infections.