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Histopathologic examination of the excised mass revealed that it was an embryonal rhabdomyosarcoma (figure 2).
Sukov and coworkers (11) found ALK gene rearrangements in 67% of tumors in a series that included 21 cases of IMTs of the urinary bladder, but found no such ALK gene rearrangement in the other tumors among 32 non-IMTs tested, including 16 leiomyosarcomas and 3 embryonal rhabdomyosarcomas.
The main differential is with well-differentiated embryonal rhabdomyosarcoma.
Sarcomas-leiomyosarcoma, embryonal rhabdomyosarcoma.
In 1998, at age 11 months, he was diagnosed with embryonal rhabdomyosarcoma of the right maxilla and underwent partial maxillectomy and temporal bone resection, followed by chemotherapy (vinblastine) and radiation therapy.
Embryonal rhabdomyosarcoma is the most common histologic variant seen in childhood; a large proportion of them arise in the head and neck-most commonly in the orbit, the nasopharynx, and the ear.
These include Adenomyoma, Embryonal rhabdomyosarcoma, Leiomyoma, and even lesions like Schwannoma, Nabothian cyst, Decidualized stroma, Plasmacytoma, Villoglandular papillary adenocarcinoma, Adenosarcoma, Non-hodgkin's lymphoma, Aggressive angiomyxoma, Gliosis of cervix etc.
14,18,19) Differentiation of embryonal rhabdomyosarcoma, with predominantly spindle cells, from JH may pose a diagnostic challenge.
The differential diagnosis of EWT includes metastatic Wilms tumor, embryonal rhabdomyosarcoma, immature teratoma, and malignant mixed mullerian tumor (MMMT).
The clinical differential diagnosis of an epididymal tumor includes tuberculosis, spermatic granuloma, adenomatoid tumor (the most common tumor in this location), mesothelioma, papillary cystadenoma (especially if the patient has a family history of von Hippel-Lindau disease), and embryonal rhabdomyosarcoma.