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any of several hereditary disorders in which most of the erythrocytes are elliptocytes; it is characterized by increased erythrocyte destruction and anemia.
A hematologic disorder in which 50-90% of the red blood cells consist of rod forms and elliptocytes; often associated with a hemolytic anemia. There are several autosomal dominant forms [MIM*130500, MIM*130600, and MIM*179650], with one form linked to the Rh blood group, caused by mutation in the gene encoding erythrocyte membrane protein band 4.1 (EPB41) on chromosome 1p, whereas the unlinked form is due to mutation either in the alpha-spectrin gene on 1q, or in the beta-spectrin gene on 14q or the band 3 gene on 17q. There is one autosomal recessive form [MIM*225450] known.
elliptocytosis/el·lip·to·cy·to·sis/ (e-lip″to-si-to´sis) a hereditary disorder characterized by elliptocytes, with increased red cell destruction and anemia.
Etymology: Gk, elleipsis + kytos + osis, condition
an abnormal condition of the blood characterized by increased numbers of elliptocytes. Less than 15% of the red blood cells appear in this form in normal blood; modest increases occur in a variety of anemias, including a rare congenital disorder, hereditary elliptocytosis. Also called ovalocytosis. Compare spherocytosis. See also acanthocytosis, congenital nonspherocytic hemolytic anemia, sickle cell anemia, spherocytic anemia.
A hereditary abnormality of hemopoiesis in which 50-90% of the red blood cells consist of rod forms and elliptocytes, often with an associated hemolytic anemia.
elliptocytosisOval-shaped red blood cells. A small proportion of oval cells occurs in MEGALOBLASTIC ANAEMIA and HYPOCHROMIC ANAEMIA. A high proportion suggests an unimportant dominant hereditary disorder.
A hereditary abnormality of hemopoiesis in which 50-90% of the red blood cells consist of rod forms and elliptocytes.
n (ovalcytosis, oval cell anemia), a hereditary anomaly in which the red blood cells are elliptical, or oval shaped, and are predisposed to hemolysis.