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A gene on chromosome 3q21-q23 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB1 regulates retinal axon guidance, ipsilaterally redirecting ventrotemporal retinal ganglion cells axons at the optic chiasm midline during nervous system development, a process that is thought to require repulsive interaction with EFNB2. In the adult nervous system, EPHB1 and EFNB3 regulate chemotaxis, proliferation and polarity of the hippocampus neural progenitors.

In addition to its role in axon guidance, EPHB1 also plays a key redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. It may also regulate angiogenesis and play a role in targeted cell migration by activating the MAPK/ERK cascade, and in adhesion by activating the JNK signalling cascade. EPHB1’s cognate/functional ephrin ligands include EFNB1, EFNB2 and EFNB3.


Ears–nose and throat, lungs, kidneys An acronym for the organs involved in Wegener's granulomatosis–WG; limited WG spares the kidneys and lacks signs of systemic vasculitis; generalized WG involves the kidneys and/or has signs of systemic vasculitis; disease exacerbation is best monitored by measuring titers of antineutrophil cytoplasmic antibodies by indirect immunofluorescence. See Wegener's granulomatosis.


a large deer; there are two species, the European elk (Alces alces) and the American moose (A. americana). The largest deer, 6 ft high at the withers and 2000 lb in weight, with a prominent Roman nose, an overhanging upper lip and a beard hanging from the lower jaw, brown body hair and white on the legs. The bulls have palmate antlers, the cows have no antlers.

elk lip
a blemish in a horse, a heavy, overhanging top lip.
References in periodicals archive ?
Being an Elks scholar gives me hope, a dream and a family," says 2014 top scholarship winner Autumn Pack, who is attending Ohio University this fall.
Dyer, son of Mark and Betty Dyer of Quartz Hill, was also presented a check for $1,000 from the Elks Lodge.
Completed applications must be turned in to the applicant's nearest Elks Lodge no later than December 7, 2012.
The Lancaster Elks sponsor local scholarships, the Youth Olympics track meet, the Hoop Shoot basketball free-throw competition and Soccer Shoot soccer competition, plus Halloween and Christmas parties for local youngsters.
The 75% rule, which will be phased in through July 2007, requires Idaho Elks to demonstrate that at least 50% of Medicare patients receive care for certain medical conditions, starting in February 2006.
For more information about Impact Grants and to see a complete list of this year's Impact Grant recipients, visit the Elks National Foundation website at www.
Girls, ages 8-9: Michelle Ramirez of Joshua School, sponsored by Lancaster Elks Lodge 1625, first; and Tahan D.
Elks has reduced the concentration of its revenue from governmental payors through the growth of private insurers, although Medicare and Medicaid continue to represent more than 60% of total revenue.
In 2003, approximately 5,500 children from the Antelope Valley participated in the Lancaster Elks Hoop Shoot.
He also has been named Elk Officer of the Year and Elk of the Month.
East Bay Cares" Program will be funded by an Impact Grant awarded to the Bristol County Elks by the Elks National Foundation.
The slogan: ``As long as a veteran is in a hospital, the Benevolent Order of Elks will never forget them.