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A gene on chromosome 3q21-q23 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB1 regulates retinal axon guidance, ipsilaterally redirecting ventrotemporal retinal ganglion cells axons at the optic chiasm midline during nervous system development, a process that is thought to require repulsive interaction with EFNB2. In the adult nervous system, EPHB1 and EFNB3 regulate chemotaxis, proliferation and polarity of the hippocampus neural progenitors.

In addition to its role in axon guidance, EPHB1 also plays a key redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. It may also regulate angiogenesis and play a role in targeted cell migration by activating the MAPK/ERK cascade, and in adhesion by activating the JNK signalling cascade. EPHB1’s cognate/functional ephrin ligands include EFNB1, EFNB2 and EFNB3.


Ears–nose and throat, lungs, kidneys An acronym for the organs involved in Wegener's granulomatosis–WG; limited WG spares the kidneys and lacks signs of systemic vasculitis; generalized WG involves the kidneys and/or has signs of systemic vasculitis; disease exacerbation is best monitored by measuring titers of antineutrophil cytoplasmic antibodies by indirect immunofluorescence. See Wegener's granulomatosis.


a large deer; there are two species, the European elk (Alces alces) and the American moose (A. americana). The largest deer, 6 ft high at the withers and 2000 lb in weight, with a prominent Roman nose, an overhanging upper lip and a beard hanging from the lower jaw, brown body hair and white on the legs. The bulls have palmate antlers, the cows have no antlers.

elk lip
a blemish in a horse, a heavy, overhanging top lip.
References in periodicals archive ?
Elk & Elk is the only Ohio law firm with five attorneys in the Top 100 Ohio and Top 50 Cleveland lists.
1 Part I - the purchase of electricity for the institutions and bodies of the City of Elk, Elk County and Municipal Department of Communications Sp.
You see, the odds of being selected for any Kentucky elk license fall somewhere between slim and none; and I did it on the first try
According to Idaho state officials, the elk that escaped from the Chief Joseph Idaho ranch represented an unprecedented threat to the health and genetic purity of the wild elk herd living in the region.
I could never figure out how wolves could eat that many elk to make a difference," he recalls.
Now, Ian Barnes of University College London and his colleagues have compared lengthy stretches of Irish elk DNA with analogous genetic segments from members of 10 living deer species.
Mature bulls, about 7-8 years old, can produce between 30 to 40 pounds of velvet each year, according to the North American Elk Breeders Association website.
To request a copy of the StayinFront Visual Elk Synchronization white paper visit the StayinFront web site at http://www.
He contends these agencies took their position to protect a multibillion dollar industry that revolves around deer and elk hunting.
As one of North America's premier trophy animals, the elk (or wapiti) can stir up more lively discussion about suitable calibers than any other species.
This itinerary is intended less as a sketch of an artist's origins, pedigree, and significance than as something of the historical and material force field that undergirded two successive van Elk shows recently on view at the Stedelijk Van Abbemuseum in Eindhoven.