electroporation therapy

A local treatment modality for malignancy which uses brief, high-intensity, pulsed electrical currents to enhance the uptake of cytotoxic drugs, vaccines, and genes into cells by producing a transient increase in cell wall permeability

electroporation therapy

Therapeutics A form of drug delivery that generates electrical pulses via an electrode placed in a tumor to enhance the ability of a chemotherapeutic–eg, bleomycin to enter tumor cells involves using electric fields to open pores in human cells to allow easier and more efficient entrance of beneficial pharmaceutical products or genes. See Drug delivery, Iontophoresis.

e·lec·tro·po·ra·tion ther·a·py

(EPT) (ĕ-lek'trō-pōr-ā'shŭn thār'ă-pē)
Investigational therapy involving use of electric fields to open pores in human cells; provides for easier and more efficient entry of genes or pharmaceutical products.
Mentioned in ?
References in periodicals archive ?
Cancer immunotherapies company OncoSec Medical (OTCQB:ONCS) said on Tuesday that the US Patent and Trademark Office (USPTO) has approved claims covering a method of treating cancerous tumors with plasmid-encoded IL-15 and electroporation therapy to the tumor having a field strength of at least 700 V/cm.
The Tweezertrodes can be used to reproduce applications requiring the caliper electrodes, including gene therapy, transdermal drug delivery and electroporation therapy.
Previously performed studies, including Phase II results unveiled in 2001, have indicated that the electroporation therapy "eliminates the need for surgical removal of tumors," Genetronics President and CEO Avtar Dhillon asserted last month at the Wells Fargo Securities Healthcare Conference.
Genetronics Biomedical is a late stage biomedical company focused on building an oncology franchise based on its proprietary electroporation therapy.
We developed two systems to enable gene delivery: the MedPulser(R) DNA Delivery System designed for intramuscular delivery of DNA plasmid and the MedPulser(R) DNA Electroporation Therapy System designed for the delivery of DNA plasmids to tumor tissue.
Genetronics is a late stage biomedical company focused on building an oncology franchise based on its proprietary electroporation therapy (EPT).
For example, our expectations concerning the significance of our patent portfolio and its enhancement by the addition of the license discussed in this press release as a means of facilitating commercialization of DNA therapeutics delivered using electroporation therapy are forward looking statements.
Genetronics is a leader in electroporation therapy with over 240 patents issued, allowed, or pending.
We have developed two systems for gene delivery, namely the MedPulser(R) DNA Delivery System designed for intramuscular delivery of DNA plasmid and the MedPulser(R) DNA Electroporation Therapy System designed for the delivery of DNA plasmids to tumor tissue.
Electroporation therapy in combination with bleomycin demonstrated a significantly (p less than 0.
We have developed two systems for gene delivery, namely the Medpulser(R) DNA Delivery System designed for intramuscular delivery of plasmid and the Medpulser(R) DNA Electroporation Therapy System designed for the delivery of plasmids to tumor tissue.
The results of the study, which achieved a 72% complete response rate and 78% objective response rate in 18 study lesions, were documented in an article entitled, "Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy).