electroporation


Also found in: Dictionary, Encyclopedia, Wikipedia.

e·lec·tro·por·a·tion

(ē-lek'trō-pōr-ā'shŭn),
A technique in which a brief electric shock is applied to cells; momentary holes open briefly in the plasma membrane, allowing the entry of macromolecules (for example, a way of introducing new DNA into a cell).

electroporation

(ĭ-lĕk′trō-pə-rā′shən)
n.
A process of applying a high-voltage electrical pulse to a living cell, causing temporary permeability of the cell membrane, through which a foreign material such as DNA may pass.

electroporation

[-pôrā′shən]
a type of osmotic transfection in which an electric current is used to produce temporary holes in cell membranes, allowing the entry of nucleic acids or macromolecules (a way of introducing new deoxyribonucleic acid into the cell). See also transfection.

electroporation

a method in which CELLS are subjected to an electrical impulse that leads to the temporary formation of pores in the cell MEMBRANE. Such pores enable commodities such as DNA, PROTEINS and ATP to pass into the cell, before the pores are repaired. Electroporation provides a means of transforming cells (see TRANSFORMATION). It can also be used to deliver DRUGS across the skin and to transfer GENETIC MATERIAL to targetted cells, in GENE THERAPY.

electroporation (i·lekˈ·trō·p·rāˑ·shn),

n technique by which cell membranes are made permeable by rapid pulses of high-voltage current. Has been used to treat cancers.

electroporation

the use of high-voltage electrical impulse to create pores through a cell membrane and allow uptake of DNA into a cell.
References in periodicals archive ?
SAN DIEGO -- Inovio Biomedical Corporation (NYSE Amex:INO), a leader in DNA vaccine design, development and delivery, announced today it has granted an option to a commercial license to develop intravascular catheters using its proprietary electroporation technology to Cardigant Medical, Inc.
5, 125-132, 2007) reported that mice bearing melanoma tumors below the skin and receiving electroporation following intratumoral administration of IL-2 pDNA had significant reductions in tumor growth compared with mice treated by IL-2 pDNA alone.
This study was the first to demonstrate that synthetic DNA vaccines delivered with electroporation can protect non-human primates from a highly pathogenic H5N1 avian influenza virus challenge," stated Dr.
We have demonstrated that our novel PENNVAX[TM] HIV DNA vaccines delivered with our CELLECTRA([R]) electroporation device can induce significantly higher and broader T-cell responses in monkey models.
Inovio's advanced electroporation devices are designed to facilitate delivery and expression of these plasmid DNA-based immunotherapeutics and have been shown in primate studies and initial Phase I data to significantly enhance antibody and T-cell immune responses over plasmid DNA delivered by other methods, suggesting the potential to provide a better protective or therapeutic effect against complex infectious diseases as well as cancers.
By this acquisition we prove our commitment to CythorLab and Intelligent Electroporation.
The study was designed to assess the use of electrical pulses generated by Inovio's proprietary electroporation technology to deliver into tumor cells a plasmid DNA encoding a cytokine, interleukin-12, which stimulates adaptive and innate immunity.
Inovio is a leader in developing human applications of electroporation using brief, controlled electrical pulses to increase cellular uptake of a useful biopharmaceutical.
This patent provides Ichor with broad coverage of an invention that provides the basis for transforming electroporation from an interesting research tool to a practical and commercially viable drug delivery technology," said Drew Hannaman, Vice President -- Research and Development of Ichor Medical Systems.
Vical is the first of our corporate partners to initiate a clinical study using our electroporation technology to enhance delivery of a gene with potential therapeutic benefits in humans.
Inovio's electroporation delivery technology is intended to enhance the potency of DNA vaccines against cancers and infectious diseases by increasing the cellular uptake of an agent by 1,000 times or more.
a late stage developer of oncology and other therapies using electroporation to deliver drugs and nucleic acids, announced today the acquisition of Oslo-based Inovio AS, a leader in patented gene delivery technology for the most efficient, nonviral method for gene transfer to skeletal muscles.