electroporation


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e·lec·tro·por·a·tion

(ē-lek'trō-pōr-ā'shŭn),
A technique in which a brief electric shock is applied to cells; momentary holes open briefly in the plasma membrane, allowing the entry of macromolecules (for example, a way of introducing new DNA into a cell).

electroporation

(ĭ-lĕk′trō-pə-rā′shən)
n.
A process of applying a high-voltage electrical pulse to a living cell, causing temporary permeability of the cell membrane, through which a foreign material such as DNA may pass.

electroporation

[-pôrā′shən]
a type of osmotic transfection in which an electric current is used to produce temporary holes in cell membranes, allowing the entry of nucleic acids or macromolecules (a way of introducing new deoxyribonucleic acid into the cell). See also transfection.

electroporation

a method in which CELLS are subjected to an electrical impulse that leads to the temporary formation of pores in the cell MEMBRANE. Such pores enable commodities such as DNA, PROTEINS and ATP to pass into the cell, before the pores are repaired. Electroporation provides a means of transforming cells (see TRANSFORMATION). It can also be used to deliver DRUGS across the skin and to transfer GENETIC MATERIAL to targetted cells, in GENE THERAPY.

electroporation (i·lekˈ·trō·p·rāˑ·shn),

n technique by which cell membranes are made permeable by rapid pulses of high-voltage current. Has been used to treat cancers.

electroporation

the use of high-voltage electrical impulse to create pores through a cell membrane and allow uptake of DNA into a cell.
References in periodicals archive ?
Trial Size Ingenio[R] Electroporation Kit for Lonza-Amaxa[R] Nucleofector[R] II/2b devices (0.
In research models, GENESIS with TRACE has yielded higher and more consistent in vivo protein expression versus fixed-parameter electroporation, even in heterogeneous tissues.
All treatments were successfully completed with a delivery of 100 pulses per pair of probes for each electroporation.
Since then, several electroporation methods have been developed to increase the transformation efficiency by the use of intact cells or combination of different cell wall weakening agents.
A Northwestern University collaboration has developed a novel microfluidic device that allows for electroporation of stem cells during differentiation, making it possible to deliver molecules during this pivotal time in a cell's life.
For electroporation, heat shock and PEG studies, bacterial cells were grown in LB media up to mid log phase.
OncoSec's electroporation device, the OncoSec Medical System, now is being used in three ongoing clinical trials to treat metastatic melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma.
He explained the process saying, "Conventional electroporation methods deliver DNA only within a very small portion of the cell surface, determined by the physics governing the interaction between an electric field and a cell.
A study of the immunological response to tumor ablation with irreversible electroporation.
This vaccine trial represents the first study in man of an infectious disease vaccine delivered with electroporation and we are excited about the product's potential.
Electroporation is a transfection technique that inserts molecular probes or pieces of DNA into cells by exposing the cells to a rapid pulse of voltage.
Genetronics Biomedical Corporation (San Diego, CA), a late stage biomedical company primarily developing cancer therapies focused on improving the quality of life of patients treated for solid tumors, has been granted United States Patent 6,763,264, entitled, "Method of Treatment Using Electroporation Mediated Delivery of Drugs and Genes.