Serum (redirected from electrophoretic serum protein determination)

serum /se·rum/ (ser´um) pl. serums, se´ra   [L.]

1. the clear portion of any liquid separated from its more solid elements.

2. blood s.

3. antiserum.

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antilymphocyte serum  (ALS) antiserum derived from animals immunized against human lymphocytes; a powerful nonspecific immunosuppressive agent that causes destruction of circulating lymphocytes.

antirabies serum  antiserum obtained from the blood serum or plasma of animals immunized with rabies vaccine; used for postexposure prophylaxis against rabies if rabies immune globulin is unavailable.

blood serum  the clear liquid that separates from blood when it is allowed to clot completely, and is therefore blood plasma from which fibrogen has been removed during clotting.

foreign serum  heterologous s.

heterologous serum 

1. that obtained from an animal belonging to species different from that of the recipient.

2. that prepared from an animal immunized by an organism differing from that against which it is to be used.

homologous serum 

1. that obtained from an animal belonging to the same species as the recipient.

2. that prepared from an animal immunized by the same organism against which it is to be used.

immune serum  antiserum.

polyvalent serum  antiserum containing antibody to more than one kind of antigen.

pooled serum  the mixed serum from a number of individuals.

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se·rum (sîrm)

n. pl. se·rums or se·ra (sîr)

1. A watery fluid, especially one that moistens the surface of serous membranes or that is exuded by such membranes when they become inflamed.

2. The clear yellowish fluid obtained upon separating whole blood into its solid and liquid components.

3. Such fluid from the tissues of immunized animals, containing antibodies and used to transfer immunity to another individual.

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Serum

Serum is blood plasma with the blood clotting proteins removed. Serum is prepared by removing blood from the subject, allowing the blood naturally to form a blood clot, and then using a centrifuge to remove the red blood cells and the blood clot. The blood clot takes the form of an indistinct clump.

Mentioned in: AIDS Tests, Hyperlipoproteinemia, Hypocalcemia, Serum Sickness, Vitamins

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serum (sir´um),

n the fluid component of the blood containing all stable constituents except fibrinogen. When blood is allowed to clot and stand, a clear yellowish fluid, the serum, separates.

serum accelerator globulin,

n See accelerator, prothrombin conversion, I.

serum marker,

n a specific indicator found in a blood test that identifies a disease.

serum protein determination, electrophoretic,

n separation of serum protein fractions (albumin, α-globulin, β-globulin, and γ-globulin) based on their different isoelectric points and mobility in an electric field. Electrophoretic patterns and concentrations are of value in evaluating the hyperglobulinemias. Electrophoretic evaluation of serum protein abnormalities is usually related to moving-boundary or paper-strip separation patterns.

serum prothrombin conversion accelerator (SPCA)

n See factor VII; thromboplastin, extrinsic.

serum sickness,

n an anaphylactoid or allergic reaction after injection of foreign serum; marked by urticarial rashes, edema, adenitis, arthralgia, high fever, and prostration.

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serum

pl. sera, serums [L.] the clear portion of any animal or plant fluid that remains after the solid elements have been separated out. The term usually refers to blood serum, the clear, straw-colored, liquid portion of the plasma that does not contain fibrinogen or blood cells, and remains fluid after clotting of blood.

Blood serum from animals whose bodies have built up antibodies is called antiserum or immune serum. Inoculation with such an antiserum provides temporary, or passive, immunity against the disease.

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serum albumin mastitis test

a high concentration of serum albumin in milk indicates the presence of mastitis in the quarter.

antilymphocyte serum

see antilymphocyte serum.

serum breaks

in classical swine fever (hog cholera) vaccination when a serum-simultaneous vaccination program is not effective and it is assumed that the hyperimmune serum was ineffective.

serum clot time

see prothrombin consumption test.

serum enzymes

enzymes of individual tissues are released into the blood when the tissue is damaged or when there is much activity in it. The levels are used as a measure of activity or injury.

serum-fast

resistant to the effects of serum.

serum glutamic-oxaloacetic transaminase (SGOT)

see aspartate aminotransferase.

serum glutamic-pyruvic transaminase (SGPT)

see alanine aminotransferase.

immune serum

serum from an immunized animal, containing specific antibody or antibodies.

serum osmolality

a measure of the number of dissolved particles per unit of water in serum. See also serum osmolality.

pooled serum

the mixed serum from a number of animals.

serum protein

see serum protein.

serum sickness

a group of immediate or antibody-mediated hypersensitivity reactions (also referred to as type III hypersensitivities) that includes Arthus reaction, serum sickness and immune complex diseases. The pathogenesis involves formation of bulky antibody-antigen complexes in the walls of small blood vessels; the complexes fix complement and cause necrosis and thrombus formation. There is infiltration of polymorphonuclear cells from which lysosomal enzymes are released.

serum-simultaneous immunization

an outdated method of vaccination, most popular at one time in the vaccination of pigs against classical swine fever (hog cholera). Live virus and antiserum to the virus were injected into the patient simultaneously; breakdowns in the system were frequent, leading to severe outbreaks of the target disease.

serum thymic factor

a humoral factor enhancing T lymphocyte responsiveness.