electron transport chain


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e·lec·tron trans·port chain

(ĕ-lek'tron trans'pōrt chān)
The final common pathway in aerobic (oxidative) metabolism. Oxygen is a cofactor.

electron transport chain

The stage of cellular respiration in which the most adenosine triphosphate is generated. In this biochemical reaction, electrons are passed along the cytochromes of a cell or mitochondrial membrane and are ultimately accepted by oxygen, producing water. Hydrogen ions (protons) are transported across the membrane. The source of the protons and electrons is primarily nicotinamide adenine dinucleotide, which is recycled during the reaction.
Synonym: cytochrome transport system
See also: chain

electron transport chain

a group of specific carrier molecules in the inner mitochondrial membrane that transfer electrons from hydrogen to oxygen. Electrochemical energy generated via electron transport is transferred to ADP to reform ATP. See also oxidative phosphorylation.
References in periodicals archive ?
Other evidence of the presence of mitochondrial dysfunction in ASD patients is the fact that genes involved in the electron transport chain are downregulated (decreased Complex I, III, IV, and V).
As the photosynthetic process is turned on and electrons start flowing from PSII acceptors to downstream components of the electron transport chain the RCIIs reopen.
This leads to formation of acetate and NADH, which are then oxidized by the mitochondrial electron transport chain.
There are three major reactions that occur in cellular respiration: glycolysis, the Krebs cycle, and the electron transport chain (ETC).
In the present investigation, we have evaluated mitochondrial LPO, 8-oxo-dG, oxidized glutathione, reduced glutathione, ATP, lipoic acid, TCA cycle enzymes and electron transport chain (ETC) complex activities in the brain of young versus aged rats.
As mentioned earlier, ethanol metabolism by CYP2E1 and NADH oxidation by the electron transport chain generate ROS that results in lipid peroxidation.
In the November 2003 Journal of Neuroscience, Emory researchers Tim Greenamyre and Todd Sherer report that rotenone does its damage within the neuron's mitochondria by inhibiting a crucial enzyme in the electron transport chain known as complex I.
State-of-the-art techniques, such as cybrid analysis of electron transport chain defects in the differentiation of nuclear encoded or mitochondrial encoded defects, are also included in this thin book.
Cytochrome C oxidase (CO) is an electron transport chain enzyme
Using our yeast-based chemogenomic screening platform and subsequent follow-up work in human cancer cells, we were able to clearly show that elesclomol works in the cell's mitochondrion, where it interacts with the electron transport chain to cause rapid cell death.

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