Increased elastic tissue and solar elastotic
65-67) With progression of the disease, granulomas become confluent and coalescent with associated fibrosis, and in time the granulomatous infiltrates regress and are replaced by broad areas of dense, paucicellular hyalinized or elastotic
fibrosis that can mimic the UIP pattern of IPF.
Pterygium is an elastotic
degeneration of the subconjunctival tissue, which proliferates as vascularised granulation tissue to encroach on to the cornea destroying the superficial layers of the stroma and Bowman's membrane.
Acquired disorders of elastic tissue: Part I: Increased elastic tissue and solar elastotic
The differential diagnosis includes benign or malignant cutaneous tumors, such as basal cell carcinoma, keratoacanthoma, squamous cell carcinoma actinic keratosis, atypical fibroxanthoma , cystic chondromalacia, elastotic
nodules of the ears, Merkel cell carcinoma, perforating dermatoses, gouty tophi, verruca vulgaris, molluscum contagiosum, cutaneous horn and pseudocyst of the auricle.
They suggested that the ocular surface inflammation might stimulate collagenolytic action that may be linked to elastotic
degeneration of conjunctiva.
They result from elastotic
degeneration of the collagen fibres or could be a product of abnormal elastogenesis or even a combination of both processes.
Exposure of skin to ultraviolet (UV) radiation can lead to deposition of excessive elastotic
material, reduction in collagen, and increased expression of matrix metalloproteinases (MMPs).
Solar elastosis results in the destruction of the coherent mechanically strong and protective fibrous network of dermal collagen, and the substitution of an amorphous gel-like elastotic
The most frequent sites for solar elastotic
changes were the face, scalp, ears, arms, hands, and shoulders.
Thick fibrous bands, haemosiderin pigment and signs of elastotic
degeneration were seen.
Beneath this region, a broad zone of electron-dense elastotic
material is evident.