Collagen bundles appear to unravel, and the individual elastic fibers show signs of elastolysis
Some studies have revealed signs of elastolysis and altered elastin content in diabetic arteries (14-16).
Furthermore, our finding of alterations in arterial fibulin-1 concentrations in relation to elastic fibers in diabetes may relate to findings from other studies showing signs of elastolysis and reduced intimal elastin content in diabetic arteries (14-16).
Gambichler T, Breuckmann F, Kreuter A, Boms S, Altmeyer P, Stucker M: Immunohistochemical investigation of mid-dermal elastolysis
Other possible mechanisms for HHCE-mediated atherogenesis include altered methylation of DNA, altered cell-membrane regulatory proteins, decreased bioavailability of nitric oxide, increased elastolysis
and collagen accumulation, over-stimulation of N-methyl-D-aspartate receptors, and excessive adhesion of monocytes and neutrophils to endothelium.
was more frequent in preulcerative lesions (p=0.