eicosanoids


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ei·co·sa·noids

(ī'kō-să-noydz),
The physiologically active substances derived from arachidonic acid, that is, the prostaglandins, leukotrienes, and thromboxanes; synthesized via a cascade pathway.
[G. eicosa-, twenty, + eidos, form]

ei·co·sa·noids

(ī-kō'să-noydz)
The physiologically active substances derived from arachidonic acid (e.g., the prostaglandins, leukotrienes, and thromboxanes); synthesized through a cascade pathway.
[G. eicosa-, twenty, + eidos, form]

eicosanoids

A general term for a range of modified polyunsaturated fatty acids, products of the metabolism of arachidonic acid. They are hormones and include prostaglandins, prostacyclins, thromboxanes and leukotrienes.

eicosanoids

a family of compounds derived from arachidonic acid (eicosatetraenoic acid). Includes prostaglandins, prostacyclin and thromboxanes, the principal mediators of inflammation.
References in periodicals archive ?
Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats.
The reduction of eicosanoid release was related to the inhibition of cyclooxygenase-2 expression.
Since OA cartilage is a site of significant COX-2 expression and prostanoid overproduction, and the chronic use of COX inhibitors is highly prevalent in OA, the insufficiency of data regarding the expression and actions of eicosanoids in cartilage is noteworthy.
The omega-3 fats produce their own version of those eicosanoids, which are kinder and gentler," he adds.
3,4) The mechanisms may be through displacement of normal FFAs in cell membranes and in the synthesis of eicosanoids etc, in a way similar to those described above for omega-3 and -6 FFAs.
Most of the functions of oxylipins derived from arachidonic acid, also called eicosanoids, are well known and primarily associated with immuno-stimulatory events (which stimulate the immune system) and pro-coagulant actions (which promote blood coagulation).
Peroxisome proliferators activated receptor-gamma (PPAR-[gamma]) is a ligand activated transcription factor and its activity is regulated by several natural ligands, including fatty acids and eicosanoids (7).
Kinases perform a variety of tasks, including chemically modifying other proteins, regulating cellular pathways (particularly those involved in the transmission of signals within the cell), and regulating substances that can negatively impact health, including eicosanoids, cytokines, and free radicals.
Our bodies have the ability to convert linoleic acid (as well as alpha-linolenic acid) into longer chain fatty acids which lead to the production of eicosanoids.
These eicosanoids are believed to be the major driver behind the CVD benefits derived from taking fish oil.
Also evident is that eicosanoids, which are made from EFAs help, regulate immune function as well as inflammation.