Catecholamines and eicosanoids
were measured by offline and online SPE-LC-MS/MS (21-22).
Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid
production, platelet aggregation and atherosclerosis in hypercholesterolemic rats.
The reduction of eicosanoid
release was related to the inhibition of cyclooxygenase-2 expression.
Since OA cartilage is a site of significant COX-2 expression and prostanoid overproduction, and the chronic use of COX inhibitors is highly prevalent in OA, the insufficiency of data regarding the expression and actions of eicosanoids
in cartilage is noteworthy.
The omega-3 fats produce their own version of those eicosanoids
, which are kinder and gentler," he adds.
3,4) The mechanisms may be through displacement of normal FFAs in cell membranes and in the synthesis of eicosanoids
etc, in a way similar to those described above for omega-3 and -6 FFAs.
Most of the functions of oxylipins derived from arachidonic acid, also called eicosanoids
, are well known and primarily associated with immuno-stimulatory events (which stimulate the immune system) and pro-coagulant actions (which promote blood coagulation).
Peroxisome proliferators activated receptor-gamma (PPAR-[gamma]) is a ligand activated transcription factor and its activity is regulated by several natural ligands, including fatty acids and eicosanoids
Kinases perform a variety of tasks, including chemically modifying other proteins, regulating cellular pathways (particularly those involved in the transmission of signals within the cell), and regulating substances that can negatively impact health, including eicosanoids
, cytokines, and free radicals.
Our bodies have the ability to convert linoleic acid (as well as alpha-linolenic acid) into longer chain fatty acids which lead to the production of eicosanoids
are believed to be the major driver behind the CVD benefits derived from taking fish oil.
Also evident is that eicosanoids
, which are made from EFAs help, regulate immune function as well as inflammation.