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eicosanoid |
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eicosanoid Physiology A 20-carbon cyclic fatty acid which with its arachidonic acid metabolites–eg, HETE, HPETE, leukotrienes, PGs, and thromboxanes, are site-specific, ↑ during shock and after injury, have diverse
functions–eg, bronchoconstriction, bronchodilation, vasodilation, vasoconstriction. See Arachidonic acid, Bad eicosanoid, Good eicosanoid, Zone-favorable diet. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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22,23,39) Thus, the major inflammatory mediators involved in the inflammatory pain induced by carrageenan are eicosanoids and sympathomimetic amines, whereas the major inflammatory mediators involved in the inflammatory pain induced by formalin are serotonin and histamine, both of which directly activate sensitized nociceptors. 41) Ludwig et al concluded that high concentrations of magnesium inhibit eicosanoid metabolism during the release of arachidonic acid by directly inhibiting the 5-lipoxygenase enzyme. ALA reduces the production of inflammatory substances, and at the same time it enhances the production of less inflammatory eicosanoids and prostaglandins. |
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