eicosanoid


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eicosanoid

(ī′kō-sə-noid′)
n.
Any of a group of substances that are derived from arachidonic acid, including leukotrienes, prostaglandins, and thromboxanes.

eicosanoid

A 20-carbon cyclic fatty acid derived from arachidonic acid that is synthesised from membrane phospholipids. Eicosanoids and other arachidonic acid metabolites (e.g., HETE, HPETE, leukotrienes, prostaglandins and thromboxanes) are site-specific, increase during shock and after injury, and have diverse functions, including bronchoconstriction, bronchodilation, vasodilation and vasoconstriction.

eicosanoid

Physiology A 20-carbon cyclic fatty acid which with its arachidonic acid metabolites–eg, HETE, HPETE, leukotrienes, PGs, and thromboxanes, are site-specific, ↑ during shock and after injury, have diverse functions–eg, bronchoconstriction, bronchodilation, vasodilation, vasoconstriction. See Arachidonic acid, Bad eicosanoid, Good eicosanoid, Zone-favorable diet.

eicosanoid

(ī-kō′să-noyd″)
Any of several autocrine or paracrine cytokines formed from the metabolism of arachidonic acid. They include prostaglandins, thromboxanes, and leukotrienes.
References in periodicals archive ?
5, 2, 5, and 16 h, aliquots were taken out of the samples to allow for each 10-12 replicates of MxP Broad Profiling, MxP Catecholamines, and MxP Eicosanoids as described below.
The [omega]-6 fatty acids are precursors of eicosanoids of the 1-series and exert an inhibitory effect on leu-cotriene synthesis (Belch and Hill 2000).
Our studies demonstrate that OA cartilage produce a remarkably broad array of eicosanoid end products.
3,4) The mechanisms may be through displacement of normal FFAs in cell membranes and in the synthesis of eicosanoids etc, in a way similar to those described above for omega-3 and -6 FFAs.
These results indicate that an optimum amount of dietary AA is necessary for normal growth, development and survival but an overdose of AA has negative effects on fish, probably through the eicosanoid production mechanism mentioned above.
1995, The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.
Third, certain polyunsaturated fatty acids (PUFAs) - specifically C20:3n-6 (eicosatrienoic), C20:4n-6 (arachidonic acid) and C20:5n-3 (eicosapentaenoic acid) - act in regulatory roles, as substrates for the biosynthesis of prostaglandins and other eicosanoids.
ROSE, DP & CONNOLLY, JM 1990: Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture.
Thrombin also cleaves glycoprotein (GP) Ib[alpha] and GP V Activation involves G proteins and the eicosanoid and the diacyglyceryl pathways and results in full secretion and aggregation.
41) Ludwig et al concluded that high concentrations of magnesium inhibit eicosanoid metabolism during the release of arachidonic acid by directly inhibiting the 5-lipoxygenase enzyme.
People hold onto stores of DHA for a long time, so you don't need to replenish levels as often as with EPA, which is turned over constantly, by conversion into eicosanoid hormones.
In humans, PUFA are precursors to eicosanoid hormones, which mediate cardiovascular disease conditions and are essential for the development of retinal and nervous tissue.