eflornithine


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eflornithine

 [ef-lor´nĭ-thēn″]
an inhibitor of the enzyme catalyzing the decarboxylation of ornithine; used topically as the hydrochloride salt to reduce unwanted facial hair in females. It has also been administered intravenously in treatment of African trypanosomiasis.

eflornithine

/ef·lor·ni·thine/ (DMFO) (ef-lor´nĭ-thēn″) an inhibitor of the enzyme catalyzing the decarboxylation of ornithine; used topically as the hydrochloride salt to reduce unwanted facial hair in females.

eflornithine

An antiprotozoal drug used to treat Pneumocystis carinii pneumonia and African TRYPANOSOMIASIS. The drug is on the WHO official list.

eflornithine

an antiprotozoal agent, used as the hydrochloride in trypanosomiasis and pneumocystiscarinii pneumonia.
References in periodicals archive ?
This combination consisted of sulindac, which is an older, established antiinflammatory medication, and [alpha]-difluoromethylornithine (DFMO), or eflornithine, a failed cancer-therapeutic drug that was later found to be a highly effective depilatory.
The currently available drugs for trypanosomiasis treatment include pentamidine (8), melarsoprol (9), and eflornithine (10).
Your GP may recommend a contraceptive pill that can suppress the hormones (androgens) that cause excess hair growth, or a cream - eflornithine - that prevents hair growth.
Sanofi will extend its existing donation of eflornithine, melarsoprol and pentamidine for sleeping sickness to 2020, as well as logistical support to ensure that the drugs continue to reach patients at the point of care cost-free.
1) Adverse reactions to eflornithine occur fairly frequently; about 25-50% of patients receiving eflornithine treatment will experience bone marrow toxicity and roughly 10% of patients experience gastrointestinal symptoms.
14) extraction Metronidazole (anti-inflammatory more than antihelmintic) Wound care Cutaneous Praziquantel 40 schistosomiasis mg/kg/day stat Sometimes repeated Systemic steroids in Katayama fever Avoidance of water in endemic areas Snail control Trypanosomiasis Nifurtimox (with gamma interferon Suramin, pentamidine Eflornithine WHO control measures Filarial Ivermectin elephantiasis Adjunctive albendazole, doxycycline Surgical correction DEC = diethylcarbamazine; ANS = autonomic nervous system; GIT = gastrointestinal; CVS = cardiovascular system; CSF = cerebrospinal fluid; PCR = polymerase chain reaction.
With the exception of antimalarials, there are currently only four drugs (suramine developed in 1921; pentamidine developed in 1941; melarsoprol developed in 1949 and eflornithine developed in 1990) approved to treat HAT (Mackey et al.
12) The prescription cream Eflornithine (Vaniqa) is sometimes prescribed in addition, to slow facial hair growth in women; this drug has been shown to be effective for about one-third of the women who have used it.
The production and distribution of the major drug eflornithine was discontinued following market failure.
Eflornithine was unavailable and treatment with melarsoprol continued.