effort syndrome


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effort syndrome

Etymology: Fr, exertion; Gk, syn, together, dromos, course
an abnormal condition characterized by chest pain; dizziness; fatigue; palpitations; cold, moist hands; and sighing respiration. The condition is often associated with soldiers in combat but occurs also in other individuals. The pain often mimics angina pectoris but is more closely connected to anxiety states and occurs after rather than during exercise. Because angina may also be associated with anxiety, positive diagnosis of effort syndrome may require an exercise electrocardiogram. Other chest pains that mimic effort syndrome and angina may be caused by musculoskeletal problems, such as inflammation of the costochondral junctions, fractured ribs, or cervical spondylosis. Also called neurocirculatory asthenia.

orthostatic intolerance

A condition (OMIM:604715) characterised by lightheadedness, fatigue, altered mentation, syncope and tachycardia upon assuming an upright position, and markedly elevated serum norepinephrine. 

Molecular pathology
Defects in SLC6A2, which encodes a member of the sodium:neurotransmitter symporter that regulates norepinephrine homeostasis, are a cause of orthostatic intolerance.

effort syndrome

Unusual or unexpected fatigue with exertion. The fatigue is increased by mild exertion and may be more pronounced in the morning.
See: chronic fatigue syndrome

effort syndrome

See DA COSTA SYNDROME.