efflux pump


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efflux pump

A cell membrane protein channel that selectively admits or excludes chemicals from the cytoplasm. In some bacteria efflux pumps prevent their cells from accumulating antibiotics, contributing to drug resistance.
See also: pump
References in periodicals archive ?
EtBr] adapted to overexpress the norA efflux pump gene, and two clinical MRSA strains with increased efflux activity; S.
They reported broad and overlapped expression patterns for three drug efflux pumps that are commonly implicated in chemotherapy resistance: the multidrug resistance protein 1 (MRP1), the breast cancer resistance protein (BCRP), and P-glycoprotein (PGP).
The compounds were also assessed for their potential activity as antibiotic modulators and efflux pump inhibitors.
Paradoxically, it is the infected macrophage itself that stimulates the efflux pumps in the bacteria.
Though all these efflux pumps have been studied well, epidemiological significance of these in the dissemination of drug resistance remains unexplored.
5) The results show that the efflux pump (mefA gene) was the most prevalent mechanism (48.
An additive effect was observed when diosmetin (64 [mu]g/ml) was combined with ciprofloxacin (8[mu]g/ml) against the NorA efflux pump overexpressed SA-1199B.
The research team is working to discover the assembled structure of the entire three-part efflux pump.
Antibiotics and inhibitors: Rifampicin, isoniazid, ethambutol, streptomycin, oloxacin, norloxacin, kanamycin and efflux pump inhibitors carbonyl cyanide m-chlorophenylhydrazone (CCCP) and verapamil were obtained from Sigma, USA.
An efflux pump mechanism is unlikely; we showed no reduction in MICs in the presence of reserpine (online Appendix Table) and this organism was fully susceptible to penicillin, tetracycline, erythromycin, and Triton X-100 (data not shown).