effective dose


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dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

ef·fec·tive dose (ED),

1. the dose that produces a specific effect; when followed by a subscript (generally "ED50"), it denotes the dose having such an effect on a certain percentage (for example, 50%) of the test animals; ED50 is the median effective dose;
2. in radiation protection, the sum of the equivalent doses in all tissues and organs of the body weighted for tissue effects of radiation. The SI unit of effective dose is the sievert (Sv) (=100 rem).
3. in diagnostic radiology, if a patient weighing W absorbs A joules of energy, and the experimentally derived ratio of effective dose to energy absorbed in an anthropomorphic phantom with mass M is R, then the effective dose is A·R·M:W. This formula results in a larger value for children despite their lesser absorption of radiation.

effective dose (ED)

1 on a graded dose-response curve in the laboratory, the dosage of a drug that may be expected to cause a response of the desired magnitude.
2 in a clinical setting, the dose needed to cause the desired response in a percentage of the people to whom it is given (e.g., an ED50 dosage of a drug is expected to produce a response in 50% of the patients receiving it).

ef·fec·tive dose

(ED) (e-fek'tiv dōs)
1. The dose that produces the desired effect; when followed by a subscript (generally "ED50"), it denotes the dose having such an effect on a certain percentage (e.g., 50%) of the test animals; ED50 is the median effective dose.
2. In radiation protection, the sum of the equivalent doses in all tissues and organs of the body weighted for tissue effects of different types of radiation. The unit of effective dose is the sievert (Sv) or rem.

ef·fec·tive dose

(ED) (e-fek'tiv dōs)
Dose that produces a specific result; when followed by a subscript (generally "ED50"), it denotes the dose having such an effect on a given percentage (e.g., 50%) of the test animals; ED50 is the median effective dose.
References in periodicals archive ?
In our study we were able to decrease the effective dose without losing any important findings that may affect the diagnoses.
use of personal monitors to estimate effective dose equivalent and effective dose to workers for external exposure to low-LET radiation.
Estimates of the effective dose from a diagnostic CT procedure can vary by a factor of 10 or more depending on the type of CT procedure, patient size and the CT system and its operating technique.
Any statements that are not historical facts contained in this release are forward-looking statements that involve risks and uncertainties, including Repros' ability to have the partial hold on Proellex lifted and to determine a safe and effective dose for Proellex, maintain its listing on the NASDAQ Capital Market, raise needed additional capital on a timely basis in order for it to continue to fund its operations and pursue its development activities, and such other risks which are identified in the Company's most recent Annual Report on Form 10-K and in any subsequent quarterly reports on Form 10-Q.
The only effective dose was the mouse equivalent to about one-tenth of a marijuana joint, considerably less than what creates a high.
This trial will assess the safety and pharmacokinetic profiles of MG98, define the optimal effective dose of MG98 in these patients --which will aid in the design of future MG98 trials -- and document both the biological and clinical effects of MG98 in patients with advanced MDS and relapsed or refractory AML.
The most effective dose reduced this viral load by 97 percent, on average, Haubrich reported late last month in Boston at the Conference on Retroviruses and Opportunistic Infection.
At approximately 10 times the effective dose there were no adverse events observed.
The comparable effective dose in humans probably would be much lower than indicated by this extrapolation, since the rat has a very high metabolism.
Daniel Glassman, President & CEO of Bradley said, "By offering the lowest effective dose of estrogen in an elegant, easy-to-use gel, Elestrin[TM] will provide physicians with an important treatment for women suffering from menopausal symptoms.
A 12-week, double-blind, placebo-controlled Phase III study of 484 symptomatic menopausal women was designed to identify the lowest effective dose to allow estrogen treatment in the safest possible manner.

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