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edrophonium test

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edrophonium test,
a test for myasthenia gravis in which an IV solution of edrophonium chloride is injected into a patient. A total of 10 mg of the cholinergic drug is prepared, and a 2-mg dose is injected. If there is no reaction in 30 seconds, the remaining 8 mg is administered. A brief improvement in muscle activity is regarded as a positive result. Edrophonium chloride is also used to distinguish between myasthenia gravis and a cholinergic crisis. Because edrophonium chloride can precipitate respiratory depression, the test should not be performed unless an anticholinergic antidote, such as atropine, and respiratory resuscitation equipment are available. For further explanation of electroencephalographic recording of brain waves, see also alpha wave, beta wave, delta wave, theta wave.


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An edrophonium test was positive with reversal of neck weakness to 5/5 power.
 
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