A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic
The paw thickness was measured immediately prior to carrageenan injection and at 1, 2, 4 and 6h after the administration of the edematogenic
agent using a spiral micrometer (Shengke Instrument Co.
nociceptive and edematogenic
responses elicited by a crude bristle extract of Lonomia obliqua caterpillars.
and myotoxic activities of a hemorrhagic metalloproteinase isolated from Bothrops alternatus venom.
The edematogenic activity was inhibited in those animals that received an injection U.
nutans showed an important dose-dependent reduction of the edematogenic activity of B.
The vascular permeability evaluated by Evans blue leakage at 30 min in the paw edema model was not altered, indicating that EP-Mt edematogenic
effect is not of osmotic nature, different from that elicited by the polysaccharide dextran (Lo, Almeida, & Beaven, 1982).
activity of scorpion venoms from the Buthid family and role of platelet-activating factor and nitric oxide in new edema induced by Tityus venoms.
1]) was tested in the acute paw edema model, and also evoked an edematogenic
action in rats, suggested by the authors as an inflammatory reaction exhibited by the SP as a defense mechanism from the immune system of the animals.
1h before the edematogenic
agent to different groups of animals for each treatment (n = 8/per group).
the intensity of the edematogenic
response to carrageenan did not change (Fig.
reaction was induced by bradykinin (50 [micro]g/paw) injected in the subplantar region of the left hind paw of Wistar rats as described by Winter et al.