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The paw thickness was measured immediately prior to carrageenan injection and at 1, 2, 4 and 6h after the administration of the edematogenic agent using a spiral micrometer (Shengke Instrument Co.
Proteolytic, edematogenic and myotoxic activities of a hemorrhagic metalloproteinase isolated from Bothrops alternatus venom.
1h before the edematogenic agent to different groups of animals for each treatment (n = 8/per group).
001) the edematogenic response evoked by carrageenan in mice.
The edematogenic reaction was induced by bradykinin (50 [micro]g/paw) injected in the subplantar region of the left hind paw of Wistar rats as described by Winter et al.