ectromelia


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ectromelia

 [ek″tro-me´le-ah]
gross hypoplasia or aplasia of one or more long bones of one or more limbs. adj., adj ectromel´ic.

ec·tro·me·li·a

(ek'trō-mē'lē-ă),
1. Congenital hypoplasia or aplasia of one or more limbs.
2. A disease of mice caused by the ectromelia virus, a member of the family Poxviridae; characterized by gangrenous loss of feet and by necrotic areas in the internal organs; in laboratory mouse colonies, it usually results in high mortality rates.
[ectro- + G. melos, limb]

ectromelia

/ec·tro·me·lia/ (ek″tro-me´le-ah) gross hypoplasia or aplasia of one or more long bones of one or more limbs.ectromel´ic

ectromelia

[ek′trōmē′lyə]
Etymology: Gk, ektrosis + melos, limb
the congenital absence or incomplete development of the long bones of one or more of the limbs. Kinds of ectromelia are amelia, hemimelia, and phocomelia. ectromelic, adj., ectromelus, n.

ec·tro·me·li·a

(ek'trō-mē'lē-ă)
1. Congenital hypoplasia or aplasia of one or more limbs.
2. A disease of mice caused by the ectromelia virus; characterized by gangrenous loss of feet and necrotic areas in the internal organs; in laboratory mouse colonies, it usually results in high mortality rates.
[ectro- + G. melos, limb]

ectromelia

congenital absence of one or more limbs

ectromelia

1. gross hypoplasia or aplasia of one or more long bones of one or more limbs.
2. a generalized poxvirus disease of mice resembling smallpox in humans. Used in studies as a model of generalized virus infections.
References in periodicals archive ?
Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.
Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic responses and overcomes genetic resistance to mousepox.
The possibility that researchers could genetically manipulate the natural enemies of non-native species to kill them faster and better, thus protecting the "natural" environment, attracted public notice in 2001, when a team of virologists, seeking to control non-native rodents in Australia, announced that it had had added an interleukin-4 gene, which suppresses the immune response, to ectromelia or mousepox virus.
A smallpox diagnostic panel compiled by Inger Damon s laboratory at the CDC included 12 different variola virus isolates (VAR), 13 different strains and isolates of camelpox, cowpox (CPV), ectromelia, herpes, monkeypox, Staphylococcus aureus, vaccinia (VV), and varicella-zoster viruses (VZV).
Posterboard 64: Attenuated Smallpox Vaccine LC16m8 Protects Mice from High-Dose Lethal Intranasal Ectromelia Challenge Administered 10 and 50 days Post-Vaccination (C.
Dr Ron Jackson, Dr Deborah Maguire, Dr Lyn Hinds and Professor Ian Ramshaw infected laboratory mice with an ectromelia (mouse pox) virus equipped with a gene coding for zone pellucida proteins.
In one of these studies, oral administration of SIGA-246 protected mice from lethal doses of ectromelia virus.
Initially, they worked on ectromelia virus infection in mice (to explain his work, Frank coined the term mousepox).
KEY WORDS: congenital abnormalities, ectromelia, farmworkers, fungicides, Goldenhar Syndrome, insecticides, micrognathism, pesticides, prevention and control, toxicity.
We evaluated the specificity of the PPV real-time PCR assay by use of DNA from several viruses, including orthopoxviruses (vaccinia, cowpox, monkeypox, ectromelia, and camelpox virus), molluscum contagiosum virus, yaba-like disease virus, human herpesviruses types 1 to 8, and adenoviruses.
Safety and Immunogenicity of Attenuated Smallpox Vaccine, LC16m8: Results from a Phase 2 Study -- Clinical Evaluation of Attenuated Smallpox Vaccine LC16m8 in Japan -- Attenuated Smallpox Vaccine LC16m8 Protects Mice from High-Dose Lethal Intranasal Ectromelia Challenge Administered 10 and 50 days Post-Vaccination -- Safety and Efficacy Study of Attenuated Smallpox Vaccine LC16m8 in Animals -- Attenuated Smallpox Vaccine LC16m8 Protects Cynomolgus Monkeys from Lethal IV Monkeypox-Zaire Challenge
The identity/similarity scores of the complete nucleotide sequences of crmB and hemagglutinin genes from patient A, in relation to other OPVs, were, respectively, Ectromelia (AF012825), 0.