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ectromelia |
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ectromelia /ec·tro·me·lia/ (ek″tro-me´le-ah) gross hypoplasia or aplasia of one or more long bones of one or more limbs.ectromel´ic
ectromelia [ek′trōmē′lyə] Etymology: Gk, ektrosis + melos, limb the congenital absence or incomplete development of the long bones of one or more of the limbs. Kinds of ectromelia are amelia, hemimelia, and phocomelia. ectromelic, adj., ectromelus, n. ectromelia 1. gross hypoplasia or aplasia of one or more long bones of one or more limbs. 2. a generalized poxvirus disease of mice resembling smallpox in humans. Used in studies as a model of generalized virus infections. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Today, technology allows genetic engineering of potentially devastating agents such as modified ectromelia virus (2), the weaponizing variola virus (former USSR) (3), the long distance dispersal of yellow fever-infested mosquitos (United States) (4), and the weaponizing of anthrax spores by many nations. In one of these studies, oral administration of SIGA-246 protected mice from lethal doses of ectromelia virus. Although the formation of typical A-type inclusions is restricted to cells infected with cowpox virus, ectromelia virus, and raccoonpox virus (2), the sequence coding the N-terminus of the protein is highly conserved in many viruses, including CPXV, VACV, variola virus, camelpox virus, and ectromelia virus. |
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