SOX4

(redirected from ecotropic viral integration site 16)

SOX4

A gene on chromosome 6p22.3 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX4 may act as a transcription regulator after forming a complex with other proteins (e.g., syndecan-binding protein) as well as play a role in apoptosis and tumourigenesis; it may mediate the downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development.