Using this combined system, the Chemistry Unit developed a method to analyze cocaine, benzoylecgonine, cocaethylene, ecgonine
methyl ester, and ecgonine
in urine and blood.
Benzoic acid is a relatively common compound, so the researchers plan to look for a simple method to sense ecgonine
A second Entropin patent application, titled "Benzoylecgonine, Ecgonine
and Ecgonidine Derivatives," is currently under consideration by the EPO.
Saliva/plasma ratios of cocaine, ecgonine
methyl ester and benzoylecgonine following controlled cocaine administration.
DAS' novel protein cocaine conjugate provides for high affinity antisera for the intended targets, as contrasted to the numerous antisera and monoclonal antibodies which bind preferentially to the inactive metabolite, benzoyl ecgonine
Sweat patch specimens were analyzed for COC, BE, EME, ecgonine
ethyl ester, cocaethylene, norcocaine, norcocaethylene, m- and p-hydroxycocaine, and m- and p-hydroxybenzoylecgonine by modifying the method published by Huestis et al.
Benzoylecgonine (BE) and ecgonine
methyl ester (EME), major metabolites of COC, have longer half-lives in plasma and oral fluid than does the parent drug (5,9,11-14).
, MED (anhydroecgonine methyl ester), and ED (anhydroecgonine) were purchased from Radian International.
Cocaine, BE, and ecgonine
methyl ester were isolated using solid-phase extraction.
The drug menu by class of substances included amphetamines, opiates (morphine-related compounds), methadone, cocaine, and cannabinoids, whereas the drug menu for identification/ quantification consisted of amphetamine, methamphetamine, morphine, codeine, 6-acetylmorphine, methadone, 1,5-dimethyl-3,3-diphenyl-2-ethylidene- pyrrolidine (EDDP), benzoylecgonine, ecgonine
methyl ester, and 11-nor-9-carboxy-[[DELTA].