ecarin

ecarin

(ē′kă-rĭn) [Gr. echis, viper]
A prothrombin activator purified from the venom of the Indian saw-scaled viper. It is used in laboratory assays of anticoagulation by prothrombin inhibitors such as hirudin.
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References in periodicals archive ?
activated partial thromboplastin time or ecarin clotting time) have been observed in a limited number of PRAXBIND-treated patients.
IV = intravenous; t-PA = tissue plasminogen activator; aPTT = activated partial thromboplastin time; INR = international normalized ratio; PT = prothrombin time; Xa = direct factor Xa inhibitors; ECT = Ecarin clotting time; TT = thrombin time.
Ecarin modified rotational thrombelastometry: a point-of-care applicable alternative to monitor the direct thrombin inhibitor argatroban.
Evaluate the local utility and practicality of validating currently available methods to quantify the anticoagulant activity of DTI (dilute thrombin time or ecarin time calibrated with dabigatran) and DFXaI (chromogenic anti-Xa assay calibrated with rivaroxaban or apixaban).
Dabigatran: diluted thrombin time or ecarin clotting time.
Successful use of recombinant hirudin and its monitoring by ecarin clotting time in patients with heparin-induced thrombocytopenia undergoing off pump coronary artery revascularization.
Most cardiac surgical units are not equipped with an ecarin clotting time point-of-care analyser (specific for bivalirudin) (11), although use of plasma modified ACT has been described (12).
Preparation of recombinant alpha-thrombin: high-level expression of recombinant human prethrombin-2 and its activation by recombinant ecarin.
The first diagnostic test, the Ecarin Clotting Time ("ECT") test, was developed to monitor the effect of Knoll's thrombin inhibitor PEG Hirudin.
The ecarin clotting time (ECT) is a global test that reflects the activity of the coagulation cascade downstream from FII (15).
ACT: activated clotting time; aPTT: activated partial thromboplastin time; CPB: cardiopulmonary bypass; ECT: Ecarin clotting time; HIT: Heparin- induced thrombocytopenia; PCI: percutaneous coronary intervention.
The authors are to be congratulated for their successful outcome and their detailed description of the modified ecarin clotting time (ECT) used to monitor the anticoagulation.