aggressive periodontitis type 1

(redirected from early onset periodontitis)

aggressive periodontitis type 1

An autosomal dominant condition (OMIM:170650) characterised by severe and protracted gingival infections, leading to tooth loss.

Molecular pathology
Defects in CTSC, which encodes cathepsin C, a ubiquitous lysosomal cysteine proteinase, cause aggressive periodontititis type 1.
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References in periodicals archive ?
Gingival inflammation and subgingival calculus as determinants of disease progression in early onset periodontitis.
This can be a manifestation of an underlying systemic disease or an aggressive early onset periodontitis.
It is typically characterised by hyperkeratosis affecting the palms of the hands and soles of the feet and early onset periodontitis with premature exfoliation of teeth [Johnes and Mason, 1980].