MVBs are formed from early endosomes, which as prelysosomal structures belong to the degradative endosomal pathway of internalized proteins.
Early endosomes can interact with the Golgi apparatus and the endoplasmic reticulum.
The formation of early endosomes and MVBs has been shown to increase upon signaling via growth factor receptors, suggesting that the cell adjusts exosome production according to its need (12,20).
Moreover, ClC5 is mainly expressed in the early endosomes
of the renal proximal tubule and intercalated cells of the cortical collecting duct (Jentsch et al.
Early endosomes are cellular compartments that receive endocytosed material and sort them for vesicular transport to late endosomes and lysosomes or for recycling to the plasma membrane (23).
V429M mutant receptor accumulated in early endosomes, and that the class 4 p.
V429M LDLR mutant could be classified as a class 5 and not a class 2 sequence variation, we used an immunofluorescence staining technique to show that the LDLR protein produced by the class 5 sequence variation accumulated in early endosome compartments (Fig.
Increased neuronal endocytosis and protease delivery to early endosomes
in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased [Beta]-amyloidogenesis.