dysplastic nevus syndrome


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dys·plas·tic ne·vus

a nevus exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and mixed tan-to-black and pink-to-red color. Microscopically these are basally nested and scattered intraepidermal melanocytes with hyperchromatic nuclei larger than those of basal keratinocytes. If multiple and associated with a family history of melanoma, these nevi have a high risk of malignant change, but isolated dysplastic nevi in the absence of a family history of melanoma are less frequently premalignant.
See also: malignant mole syndrome.
See: dysplastic nevus syndrome.

dysplastic nevus syndrome

an inherited genetic syndrome that causes the individual to have a large number of nevi (moles), often 100 or more. These nevi tend to become dysplastic and predispose the individual to the development of malignant melanoma. Also called familial atypical mole-malignant melanoma syndrome (FAMMM) and B-K mole syndrome.

dys·plas·tic ne·vus syn·drome

(dis-plas'tik nē'vŭs sin'drōm)
Clinically atypical nevi having variable pigmentation and ill-defined borders, with an increased risk for development of cutaneous malignant melanoma; biopsies show melanocytic dysplasia.

Dysplastic nevus syndrome

A familial syndrome characterized by the presence of multiple atypical appearing moles, often at a young age.
Mentioned in: Malignant Melanoma
References in periodicals archive ?
There's a condition called dysplastic nevus syndrome, where individuals with multiple clinically atypical looking moles need careful vigilance; again I'd recommend caution with sun exposure, and definitely avoiding burning.
Sporadic dysplastic nevus syndrome is a spontaneous mutation that increases the relative risk of malignancy up to 46 times that of the general population, he said.
2000) and several other precancerous conditions such as preleukemic states of adult T-cell leukemia (Nishino 1988), dysplastic nevus syndrome (Caporaso et al.
Cytogenetics in hereditary malignant melanoma and dysplastic nevus syndrome: is dysplastic nevus syndrome a chromosome instability disorder?
Part of the University of Pittsburgh Cancer Center, it serves as an international referral center for patients with melanoma and Dysplastic Nevus Syndrome.
7% of children had sporadic dysplastic nevi and 9% had dysplastic nevus syndrome.
Gross at Skin Surgery Medical Group specializes in the following: skin cancer diagnosis and treatment including but not limited to melanoma, basal cell cancer, squamous cell cancer; diagnosis and treatment of moles and melanoma including sentinel node biopsy of lymph nodes; Mohs Surgery of skin cancer; evaluation and treatment of dysplastic nevus syndrome including use of episope evaluation of moles; skin flaps; skin grafts (full thickness and split thickness); cryosurgery for precancer and cancer; skin cancer surgery of lips, nails, ears, eyelids, and scalp; interferon for cancer, warts, and other skin problems.
It is not clear if patients with dysplastic nevus syndrome have higher incidence of conjunctival nevi.
Cytogenetic analysis of conjunctival melanoma in a patient with dysplastic nevus syndrome revealed a clonal 1;14 translocation.