dysplastic nevus


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dys·plas·tic ne·vus

a nevus exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and mixed tan-to-black and pink-to-red color. Microscopically these are basally nested and scattered intraepidermal melanocytes with hyperchromatic nuclei larger than those of basal keratinocytes. If multiple and associated with a family history of melanoma, these nevi have a high risk of malignant change, but isolated dysplastic nevi in the absence of a family history of melanoma are less frequently premalignant.
See also: malignant mole syndrome.
See: dysplastic nevus syndrome.

dysplastic nevus

an acquired atypical nevus with an irregular border, indistinct margin, and mixed coloration, often occurring in large numbers and often a precursor of malignant melanoma.
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Dysplastic nevus

dysplastic nevus

Dermatology A premalignant skin lesion characterized by irregular, > 5 mm in diameter macules numbering from a few to hundreds with a central papule, variegated dark color and lenticular changes

dys·plas·tic ne·vus

(dis-plastik nēvŭs)
Skin malformation exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and colored tan-to-black and pink-to-red.
References in periodicals archive ?
Weedon, (6) who seems to consider lentiginous melanoma as synonymous with atypical lentiginous junctional dysplastic nevus (of the elderly) (see discussion below), reported, in a letter, his personal experience with more than 100 cases and stated that this entity has "a propensity for the shoulders/upper back/deltoid region of the elderly," but it also occurs in younger individuals, especially on the lower legs of females.
Prevalence of primary acquired melanosis and nevi of the conjunctiva and uvea in the dysplastic nevus syndrome: a case-control study.
Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma.
A dysplastic nevus is flat, asymmetric in outline, has irregular borders, and has variable pigmentation.
Sporadic dysplastic nevus syndrome is a spontaneous mutation that increases the relative risk of malignancy up to 46 times that of the general population, he said.
a family history of melanoma skin cancer or other conditions that are more likely to develop into skin cancer (such as dysplastic nevus syndrome, see "Diagnosis" section)
Dysplastic nevus syndrome with multiple primary amelanotic melanomas in oculocutaneous albinism.