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dyskeratosis

   Also found in: Encyclopedia 0.02 sec.
dyskeratosis /dys·ker·a·to·sis/ (-ker-ah-to´sis) abnormal, premature, or imperfect keratinization of the keratinocytes.dyskeratot´ic
dys·ker·a·to·sis (ds-kr-tss)
n.
1. Premature keratinization in cells that are not in the keratinizing surface layer of the skin.
2. Keratinization of the corneal epithelium.

dys·kera·totic (-ttk) adj.

dyskeratosis
[dis′kerətō′sis]
Etymology: Gk, dys + keras, horn, osis, condition
an abnormal or premature keratinization of epithelial cells.

dyskeratosis (dis´kertō´sis),
n an irreversible alteration in the maturation of stratified squamous epithelium. Refers to an increase of abnormal mitosis, individual cell keratinization, epithelial pearls within the spinous layer, loss of polarity of the cells, hyperchromatism, nuclear atypia, and basilar hyperplasia.
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Dyskeratosis.

dyskeratosis
abnormal, premature or imperfect keratinization of the keratinocytes as in primary seborrhea.

dyskeratosis
Abnormal process which, in the eye, results in hornification of the epithelial layer of the conjunctiva or cornea. It may be hereditary or due to irritation (e.g. radiation) or to prolonged drug administration in the eye. It appears as a dry white plaque (called leucoplakia or leucokeratosis). It may be benign or malignant, in which case it must be surgically excised. See pterygium.


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They have abundant eosinophilic cytoplasm, but they rarely show keratin pearl formation or dyskeratosis.
Finally, human genetic disorders such as Dyskeratosis Congenita that cause decreased telomerase activity in all cells throughout life show shortened telomeres at birth and rapid progression to diseases in highly proliferative tissues such as bone marrow and skin.
There was pleomorphism, dyskeratosis, anisocytosis, and atypical mitotic figures within the cells of the superficial layers of stratified squamous epithelium.
 
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