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dysgerminoma
(redirected from dysgerminomas)

   Also found in: Encyclopedia 0.02 sec.
dysgerminoma /dys·ger·mi·no·ma/ (-jer″mĭ-no´mah) a malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad; it is the counterpart of the classical testicular seminoma.
dys·ger·mi·no·ma or dis·ger·mi·no·ma (ds-jûrm-nm)
n.
A rare malignant ovarian neoplasm composed of undifferentiated gonadal germinal cells.

dysgerminoma
[dis′jərminō′mə] pl. dysgerminomas, dysgerminomata
Etymology: Gk, dys + L, germen, germ; Gk, oma, tumor
a rare malignant tumor of the ovary that occurs in young women and is believed to arise from the undifferentiated germ cells of the embryonic gonad. The tumor is histologically identical to seminoma. Dysgerminomas are extremely sensitive to irradiation and chemotherapy, and most patients retain their fertility. Also called embryoma of the ovary, ovarian seminoma.

dysgerminoma
a solid, often radiosensitive, malignant ovarian neoplasm derived from undifferentiated germinal cells; the counterpart of seminoma of the testis.


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24-27 Studies of gonadal germ cell tumors have demonstrated the consistent nuclear immunoexpression of OCT4 by classic seminomas, dysgerminomas, embryonal carcinomas, the germ cell components of gonadoblasto-mas, and neoplastic intratubular germinal elements in the testis.
11 As with ovarian dysgerminomas and testicular seminomas, intracranial germinomas are known to show immunoreactivity for placental alkaline phosphatase (PLAP) in a surface membrane or, somewhat less commonly, diffuse cytoplasmic distribution.
In view of the sensitivity of dysgerminomas to chemotherapy, unilateral salpingo-oophorectomy with preservation of the contralateral ovary and uterus is sufficient in most patients who desire to preserve fertility, even in the presence of metastatic disease.
 
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