dynorphin


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dy·nor·phin

(dī'nōr-fin),
An endogenous opioid ligand that acts as an agonist at opiate receptors. Extremely potent, widely distributed neuropeptide that has 17 amino acid residues and contains leu5-enkephalin as its NH2-terminal sequence.

dynorphin

/dy·nor·phin/ (di-nor´fin) any of a family of opioid peptides found throughout the central and peripheral nervous systems; most are agonists at opioid receptor sites. Some are probably involved in pain regulation and others in the hypothalamic regulation of eating and drinking.

dynorphin

[dīnôr′fən]
an endogenous opioid derived from the prohormone prodynorphin. It is a neuroactive peptide with potent analgesic effects.

dynorphin

(dī-nŏr′fĭn)
An opiate-like chemical found in the brain, which blocks transmission of pain signals along nerve fibers.
References in periodicals archive ?
Enkephalin has an analgesic effect to the brain and spinal cord, endorphin in the brain while dynorphin to the spinal cord.
Products of prodynorphin processing include dynorphin A(1-17), dynorphin A(1-8), and dynorphin B(1-29).
Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, and are relevant to addiction disorders.
TENS has resulted in increased levels of Y-amino-butyric acid (GABA), endorphin, encephalin and dynorphin in spinal cord (41,42).
37) Other neuroendocrine substances and structures involved include, but not limited to, serotonin, norepinephrine, N-methyl-D-aspartate receptors, opioid peptide receptors, [gamma]-Aminobutyric acid (GABA) systems, dynorphin, acetylcholine, corticotrophin releasing factor, adrenocorticotropic hormone, and corticosterone.
Thus, deregulation of noradrenaline, dynorphin, vasopressin, orexin, and substance P all appear to play a role in alcohol dependence (Koob 2008).
Immunoreactivity to dynorphin, an endogenous opioid, is also increased in regions of histopathologic damage, and decreased blood flow in rat brain following fluid-percussion TBI [48].
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.
Instead of controlling an immunity-related gene, as Penninger's team expected, DREAM appears to suppress the production of a natural opioid called dynorphin.
NTI is seeking to out-license Dynorphin A, a human peptide previously tested as an analgesic agent.
The effect of food and water deprivation on post-stress analgesia in mice and levels of beta-endorphin and dynorphin in blood plasma and hypothalmus.