DCTN3

(redirected from dynactin subunit 3)

DCTN3

A gene on chromosome 9p13  that encodes dynactin-3 (the smallest subunit of dynactin), a macromolecular complex that binds to both microtubules and cytoplasmic dynein and effect an array of motor activities, including ER-to-Golgi transport, centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning and axonogenesis. Dynactin-3 is primarily an alpha-helical protein; it only exists as a part of the dynactin complex.