DCTN1

(redirected from dynactin 1)

DCTN1

A gene on chromosome 2p13 that encodes dynactin-1 (the largest subunit of dynactin), a macromolecular complex that binds to both microtubules and cytoplasmic dynein and effect an array of motor activities, including ER-to-Golgi transport, centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning and axonogenesis.
 
Molecular pathology
DCTN1 mutations cause distal hereditary motor neuronopathy type VIIB (HMN7B).
References in periodicals archive ?
The genetic test was performed with a panel of 27 genes [Supplementary Material 1], and a novel mutation was found in dynactin 1 (c.