Cholestatic liver disease with ductopenia
(vanishing bile duct syndrome) in Hodgkin's disease: Report of a case.
Histologically, the liver biopsy reveals a chronic necroinflammatory disorder characterized by nonspecific findings such as portal mononuclear cell infiltrate, periportal lesion (sometimes referred to as piecemeal necrosis or interface hepatitis), bile duct changes, destructive, and non destructive cholangitis and ductopenia
present in 25% of patients, plasma cell infiltrate and liver fibrosis.
The panel also selected incompatible histologic features, such as cholestasis, evidence of bile duct injury, and ductopenia
The significance of donor-specific HLA antibodies in rejection and ductopenia
development in ABO compatible liver transplantation.
Idiopathic adulthood ductopenia
(IAD), for the first time, was reported in 1988 .
Some useful clues that favor acute cellular rejection include a mixed portal inflammatory infiltrate with eosinophils, bile duct damage that is more diffuse and severe than expected in chronic hepatitis, possible ductopenia
, central perivenulitis that involves majority of central veins and less lobular necroinflammatory activity and interface activity24.
The inflammation may spill into the surrounding periportal areas and ductopenia
in another wise unremarkable liver biopsy should raise the specter of primary biliary cirrhosis.
Se realiza biopsia hepatica reportandose con ductopenia
y colestasis intracelular focal, sin observar fibrosis por lo que se diagnostica CEP asociada a CU.
11) The degree of alkaline phosphatase elevations generally correlates with the severity of ductopenia
However, in 1982 a more severe injury characterised by progressive ductopenia
was described and the term VBDS was introduced.
Tambien pueden presentar lesiones aisladas de inflamacion penivenular y perdida de celulas hepatocitarias (perivenulitis central), y evolucionar a un rechazo cronico con perdida ductal y finalmente ductopenia
The histologic criteria for cGVHD include the findings of bile duct damage and/or ductopenia
with infiltration of the smaller bile ducts with lymphocytes and eosinophils, portal area expansion with both lymphocytes and plasma cells and the presence of cholestasis [57,58].