These specimens were reportedly collected for a study initiated by Cytyc Corporation called SEDE, or Serial Evaluation of Ductal Epithelium, to investigate the relationship between the production of nipple aspirate fluid, ductal lavage
, and long-term breast health outcomes.
for detection of cellular atypia in women at high risk for breast cancer.
Using an outcomes database called the Ductal Lavage
Outcomes Tracking System, the investigators identified 31 women with lobular neoplasia who underwent ductal lavage
Investigators found poor agreement between cytologic and histologic findings and a sensitivity of ductal lavage
of only 13%-42%, depending on how a positive result was defined.
This two-step approach to obtaining nipple aspirate fluid and offering ductal lavage
to those with positive results enables gynecologists to stratify women at high risk for breast cancer.
Khan said that although she gets lots of inquiries about ductal lavage
from patients and physicians, she and her Northwestern colleagues are "relatively conservative" about recommending the procedure, largely reserving it for high-risk women who want a further assessment before deciding on a risk-lowering strategy such as tamoxifen.
The trial results establish ductal lavage
using the Pro Duct Health microcatheter as a simple, well-tolerated, safe, and minimally invasive office procedure for cytologic assessment of the milk ducts, where 95% of breast cancers arise, said Dr.
SAN ANTONIO - Breast ductal lavage
detected premalignant or frankly cancerous cells in one-quarter of high-risk but mammographically negative women in a multicenter trial, Dr.