druggable

(redirected from drugable)

druggable

, drugable (drŭg′ă-bĕl)
1. Amenable to treatment with drugs or susceptible to alteration or manipulation with drugs.
2. In genetics, pert. to the ability of a molecule to regulate the function of an endogenous protein for the benefit of the organism.
druggabilitydrugability (-bil′ĭt-ē)
References in periodicals archive ?
Novan is a privately-held, clinical stage biotechnology company advancing therapies for skin diseases using drugable nitric oxide.
The delivery technology is applied to single stranded (antisense) nucleic acid compounds with the potential to revolutionize the treatment of cancer and other diseases where drugable targets of disease are well characterized.
Targeting cellular function as a system rather than on the level of the single target, significantly increases the size of the drugable proteome and is expected to introduce novel classes of multi-target drugs with fewer adverse effects and toxicity.
Kinases are crucial mediators of important disease pathways representing more than 22% of the drugable genome.
Jin and his team have defined a new, potentially drugable target for treating cardiac hypertrophy, yet much more research is needed to determine if the findings hold beyond the current study," said Dr.
Germantown, MD), have entered into an agreement to collaborate on the identification, discovery and validation of drugable screening targets.
Although many in the field argue that GPCRs represent readily drugable targets, this has certainly not proven to be correct for those receptors which are activated by complex peptides.
Paradigm has established a powerful biological platform to define the potential clinical utility of large numbers of novel human drugable gene targets and is now ideally positioned to start the development of drugs to these targets," said Dr.
The delivery technology can be applied both to single stranded (antisense) nucleic acid compounds and double stranded (siRNA) with the potential to revolutionize the treatment of cancer and other diseases where drugable targets of disease are well characterized.
The WT1 protein is not drugable by traditional approaches, but it can be targeted by the immune system, in particular by CD4 T cells and CD8 T cells.
Nautilus Biotech and Creabilis Therapeutics entered into collaboration in September 2004 with the aim to develop a drugable variant of native HMBG1 Box A with improved PK/PD characteristics to be used as a direct antagonist of HMGB1 to treat related pathologies including hepatitis B, rheumatoid arthritis, SLE, melanoma, sepsis and MS and/or as inhibitor of RAGE to treat diabetes complications and inflammatory diseases.
The PNDRC classifies their scientific findings according to criteria such as directionality of the changes, pathways, gene ontology terms and drugable targets.