druggable

(redirected from drugable)

druggable

, drugable (drŭg′ă-bĕl)
1. Amenable to treatment with drugs or susceptible to alteration or manipulation with drugs.
2. In genetics, pert. to the ability of a molecule to regulate the function of an endogenous protein for the benefit of the organism.
druggabilitydrugability (-bil′ĭt-ē)
References in periodicals archive ?
MetaStat is developing therapeutic product candidates and paired companion diagnostics based on a novel approach that makes the Mena isoform protein a drugable target.
Forge has been applying its metal-binding pharmacophores ("MBP") library and processes and has been able to identify potent drugable inhibitors of LpxC.
Forge Therapeutics has been implementing its proprietary metal-binding pharmacophores library and processes and has been able to identify potent drugable inhibitors of LpxC.
Most recently, 2 further rearrangements have been discovered involving neurotrophic receptor tyrosine kinase 1 gene (NTRK1) and neuregulin 1 gene (NRG1), adding to the growing number of potentially drugable gene rearrangements in lung cancer.
The delivery technology is applied to single stranded (antisense) nucleic acid compounds with the potential to revolutionize the treatment of cancer and other diseases where drugable targets of disease are well characterized.
Targeting cellular function as a system rather than on the level of the single target, significantly increases the size of the drugable proteome and is expected to introduce novel classes of multi-target drugs with fewer adverse effects and toxicity.
Jin and his team have defined a new, potentially drugable target for treating cardiac hypertrophy, yet much more research is needed to determine if the findings hold beyond the current study," said Dr.
Germantown, MD), have entered into an agreement to collaborate on the identification, discovery and validation of drugable screening targets.
Although many in the field argue that GPCRs represent readily drugable targets, this has certainly not proven to be correct for those receptors which are activated by complex peptides.
Paradigm has established a powerful biological platform to define the potential clinical utility of large numbers of novel human drugable gene targets and is now ideally positioned to start the development of drugs to these targets," said Dr.
The delivery technology can be applied both to single stranded (antisense) nucleic acid compounds and double stranded (siRNA) with the potential to revolutionize the treatment of cancer and other diseases where drugable targets of disease are well characterized.
The delivery technology can be applied both to double stranded (siRNA) and single stranded (antisense) nucleic acid compounds with the potential to revolutionize the treatment of cancer and other diseases where drugable targets of disease are well characterized.