Functional predictions for targets, such as interaction partners, biological functions and drugability
, are crucial for drug discovery and disease modelling.
particularly in the demonstration of drugability
of the validated targets to
Bio-assays early = an immediate focus on drugability
= higher success; Less wet chemistry = more "shots on goal" per dollar invested; Without HTS or virtual library screening.
This collaboration aims to improve drugability
features (increasing efficacy, potency, selectivity and stability, while reducing possibly unwanted side-effects such as toxicity) of one promising lead candidate peptide identified in animal venom by Atheris, Debiopharm and the Ecole polytechnique federale de Lausanne (EPFL).
IPA can support a wide range of research objectives across our target and biomarker discovery programs - such as providing insight into target efficacy, drugability
and, increasingly, toxicity.
NeoGenesis, founded in 1997, has developed a highly efficient Chemical Genomics strategy that utilizes drug-like, small molecule ligands very early in the discovery process to empirically determine the biological utility and drugability
of poorly characterized, disease-associated proteins.
In addition, we launched a new product offering, TargetStar(TM), that allows our pharmaceutical and biotech customers to predict the drugability
of drug targets.
Thus, precise knowledge of the function of a particular cellular protein is gained, from which the protein's drugability
properties can be determined.