drug-induced systemic lupus erythematosus


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drug-induced systemic lupus erythematosus

A group of signs and symptoms similar to those of systemic lupus erythematosus, caused by an adverse reaction to drugs, esp. procainamide, hydralazine, and isoniazid. Joint inflammation and pain, skin rash, pleurisy, and fever are the most common manifestations; kidney and central nervous system involvement are rare. Antinuclear antibodies, specifically against the histones that fold DNA, are common. Some patients develop antinuclear antibodies but do not develop lupus-like symptoms. The lupus-like syndrome usually disappears when the drug causing it is discontinued. See: antinuclear antibodies; systemic lupus erythematosus
See also: lupus
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