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Related to drug tolerance: drug withdrawal
1. the ability to bear something potentially difficult.
2. the ability to endure unusually large doses of a poison or toxin.
3. drug tolerance. adj., adj tol´erant.
acquired drug tolerance drug tolerance.
ambiguity tolerance the ability to withstand conflicting or complex situations without undue psychological stress.
drug tolerance a decreasing response to repeated constant doses of a drug or the need for increasing doses to maintain a constant response. See also drug dependence and habituation.
immunologic tolerance specific nonreactivity of lymphoid tissues to a particular antigen capable under other conditions of inducing immunity.
standing tolerance the amount of time an individual is capable of maintaining an erect, upright position.
1. an exercise test to determine the efficiency of the circulation.
2. a test to determine the body's ability to metabolize a substance or to endure administration of a drug.
drug tolerancePsychiatry Repeated use of some substance or drug, often narcotics, so that ever larger doses are required to produce the same physiologic and/or psychologic effect obtained previously by a smaller dose.
drug toleranceA progressive reduction in the effect of a drug, following repeated exposure to it, so that it no longer has the desired effect in the original dose.
the ability to endure without effect or injury.
1. decreased susceptibility to the effects of a drug due to its continued administration.
2. the maximum permissible level of a drug in or on animal feed or food at any particular time relative to slaughter.
in immunology, that induced by the intravenous administration of high doses of aqueous proteins.
specific nonreactivity of the immune system to a particular antigen, which is capable under other conditions of inducing an immune response. There is, under normal circumstances, tolerance to self-antigens; identical (monozygotic) twins and dizygotic cattle or sheep twins where there has been placental fusion and exchange of bone marrow stem cells are also tolerant of each other's tissues. Allophenic mice, that is mice produced by fusion of blastocysts from different mice are also tolerant of both 'parents'. The administration of antigens either at high or low dose and infection with certain viruses during critical early stages of immunological development may also induce tolerance.
the concentration of a drug or chemical permitted by law to be present in human food.
the numerical limits within which a previously identified proportion of values of a variable, or observations in a population, can be expected to occur.
that induced by repeated administration of low doses of the antigen.
that induced by oral administration of the antigen.
the non-reactivity of the immune system to self-antigens.
see tolerance test.
when no detectable amount of a chemical substance is permitted in human food.